1253972-45-0Relevant academic research and scientific papers
Identification of 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural optimization
Zhao, Fei,Zhang, Le-Duo,Hao, Yu,Chen, Na,Bai, Rui,Wang, Yu-Ji,Zhang, Chun-Chun,Li, Gong-Sheng,Hao, Li-Jun,Shi, Chen,Zhang, Jing,Mao, Yu,Fan, Yi,Xia, Guang-Xin,Yu, Jian-Xin,Liu, Yan-Jun
, p. 147 - 158 (2017)
c-Met/HGF signaling pathway plays an important role in cancer progression, and it was considered to be related to poor prognosis and drug resistance. Based on metabolite profiling of (S)-7-fluoro-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyrazin
INHIBITORS OF ACETYL-COA CARBOXYLASE
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Page/Page column 114-115, (2010/11/17)
The present invention relates to compounds that act as acetyl-CoA carboxylase (ACC) inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
