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1254977-87-1

1254977-87-1

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1254977-87-1 Usage

Description

JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2; EC50 = 17 nM in CHO cells expressing the human receptor). In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50 = 5.4 mg/kg).

Check Digit Verification of cas no

The CAS Registry Mumber 1254977-87-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,9,7 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1254977-87:
(9*1)+(8*2)+(7*5)+(6*4)+(5*9)+(4*7)+(3*7)+(2*8)+(1*7)=201
201 % 10 = 1
So 1254977-87-1 is a valid CAS Registry Number.

1254977-87-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(Cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluorometh yl)[1,2,4]triazolo[4,3-a]pyridine

1.2 Other means of identification

Product number -
Other names 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1254977-87-1 SDS

1254977-87-1Downstream Products

1254977-87-1Relevant articles and documents

Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8- trifluoromethyl[1,2,4]triazolo[4,3- a ]pyridine (JNJ-42153605): A positive allosteric modulator of the metabotropic glutamate 2 receptor

Cid, Jose María,Tresadern, Gary,Vega, Juan Antonio,De Lucas, Ana Isabel,Matesanz, Encarnación,Iturrino, Laura,Linares, María Lourdes,Garcia, Aránzazu,Andrés, José Ignacio,MacDonald, Gregor J.,Oehlrich, Daniel,Lavreysen, Hilde,Megens, Anton,Ahnaou, Abdellah,Drinkenburg, Wilhelmus,MacKie, Claire,Pype, Stefan,Gallacher, David,Trabanco, Andrés A.

, p. 8770 - 8789 (2013/01/15)

Advanced leads from a series of 1,2,4-triazolo[4,3-a]pyridines with mGlu2 receptor PAM activity are reported. By modification of the analogous imidazo[1,2-a]pyridine series, the newly reported leads have improved potency, in vitro ADMET, and hERG as well

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