1256161-69-9

Upstream product

• 761434-42-8 (R)(-)-2-[1-(4-chlorophenyl)-2-nitroethyl]malonic acid dimethyl ester 
• 101671-01-6 1-nitro-2-(4-chlorophenyl)ethylene 
• 360072-54-4 methyl 2-carbomethoxy-4-nitro-3-(4-chloro-phenyl)-butyrate 

Downstream Products

• 123632-35-9 (R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 63701-55-3 (R)-(-)-baclofen hydrochloride 
• 834917-64-5 (R)-4-(4-Chloro-phenyl)-2-oxo-pyrrolidine-3-carboxylic acid 

Relevant academic research and scientific papers

Squaramide-Catalyzed Michael Addition as a Key Step for the Direct Synthesis of GABAergic Drugs

Enantioselective organocatalytic Michael additions serve as the key step in syntheses of chiral drugs based on γ-aminobutyric acid. The applicability of various squaramide catalysts for these Michael-type reactions has been assessed. Very good results in

Biscinchona alkaloids as highly efficient bifunctional organocatalysts for the asymmetric conjugate addition of malonates to nitroalkenes at ambient temperature

The novel bifunctional bisalkaloids have been developed as highly efficient catalysts for the asymmetric conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes with low catalyst loading (1 mol %) at ambient temperature, providing the products with