834917-64-5

Upstream product

• 834917-63-4 ethyl (4R)-4-(4-chlorophenyl)-2-oxopyrrolidine-3-carboxylate 
• 101671-01-6 1-nitro-2-(4-chlorophenyl)ethylene 
• 104-88-1 4-chlorobenzaldehyde 
• 834917-62-3 (R)-ethyl 2-carboethoxy-4-nitro-3-(4-chlorophenyl)butyrate 
• 1256161-69-9 methyl (4R)-4-(4-chlorophenyl)-2-oxopyrrolidine-3-carboxylate 
• 360072-54-4 methyl 2-carbomethoxy-4-nitro-3-(4-chloro-phenyl)-butyrate 

Downstream Products

• 123632-35-9 (R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 63701-55-3 (R)-(-)-baclofen hydrochloride 

Relevant academic research and scientific papers

Squaramide-Catalyzed Michael Addition as a Key Step for the Direct Synthesis of GABAergic Drugs

Enantioselective organocatalytic Michael additions serve as the key step in syntheses of chiral drugs based on γ-aminobutyric acid. The applicability of various squaramide catalysts for these Michael-type reactions has been assessed. Very good results in

Enantio- and diastereoselective michael reaction of 1,3-dicarbonyl compounds to nitroolefins catalyzed by a bifunctional thiourea

We synthesized a new class of bifunctional catalysts bearing a thiourea moiety and an amino group on a chiral scaffold. Among them, thiourea 1e bearing 3,5-bis(trifluoromethyl)benzene and dimethylamino groups was revealed to be highly efficient for the as