360072-54-4Relevant academic research and scientific papers
Helical Oligourea Foldamers as Powerful Hydrogen Bonding Catalysts for Enantioselective C-C Bond-Forming Reactions
Bécart, Diane,Diemer, Vincent,Salaün, Arnaud,Oiarbide, Mikel,Nelli, Yella Reddy,Kauffmann, Brice,Fischer, Lucile,Palomo, Claudio,Guichard, Gilles
supporting information, p. 12524 - 12532 (2017/09/23)
Substantial progress has been made toward the development of metal-free catalysts of enantioselective transformations, yet the discovery of organic catalysts effective at low catalyst loadings remains a major challenge. Here we report a novel synergistic
A thiourea-functionalized metal-organic macrocycle for the catalysis of Michael additions and prominent size-selective effect
Yang, Lu,Zhao, Liang,Zhou, Zhen,He, Cheng,Sun, Hui,Duan, Chunying
supporting information, p. 4086 - 4092 (2017/03/30)
A discrete tetranuclear thiourea-based metal-organic macrocycle (MOM) with a large size was constructed by a well-designed organic ligand and nickel(ii) ions via self-assembly. Incorporating thiourea groups as hydrogen-bond donors into a metal-organic com
Divergent Reactivity of Nitrocyclopropanes with Huisgen Zwitterions and Facile Syntheses of 3-Alkoxy Pyrazolines and Pyrazoles
Yang, Changjiang,Liu, Wei,He, Zijian,He, Zhengjie
supporting information, p. 4936 - 4939 (2016/10/18)
A novel annulation reaction of trans-2-substituted-3-nitrocyclopropane-1,1-carboxylates with in situ generated Huisgen zwitterions is reported, providing facile synthesis of 3-alkoxy pyrazolines in good yields and high diastereoselectivities. This reactio
Efficient synthesis of β-aryl-γ-lactams and their resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen
Montoya-Balbás, Iris J.,Valentín-Guevara, Berenice,López-Mendoza, Estefanía,Linzaga-Elizalde, Irma,Ordo?ez, Mario,Román-Bravo, Perla
, p. 22028 - 22043 (2016/01/25)
An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained, followed by the reduction of the γ-nitroester in the presence of Raney nickel and the subsequent saponification/decarboxylation reaction. The utility of this methodology was highlighted by the preparation of enantiomerically-pure (R)- and (S)-Baclofen hydrochloride.
Multisite organic-inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs
Leyva-Perez, Antonio,Garcia-Garcia, Pilar,Corma, Avelino
supporting information, p. 8687 - 8690 (2014/08/18)
Multisite organic-inorganic hybrid catalysts have been prepared and applied in a new general, practical, and sustainable synthetic procedure toward industrially relevant GABA derivatives. The domino sequence is composed of seven chemical transformations which are performed in two one-pot reactions. The method produces both enantiomeric forms of the product in high enantiopurity as well as the racemate in good yields after a single column purification step. This protocol highlights major process intensification, catalyst recyclability, and low waste generation.
Iodine-promoted synthesis of 3-arylindolizine-1-carboxylates from 2-(2-nitro-1-arylethyl)malonates and pyridine
Li, Yun,Zhou, Zhengquan,Ye, Weijian,Liu, Juanjuan,Yao, Juan,Wang, Cunde
, p. 526 - 530 (2013/10/22)
An efficient and straightforward one-pot synthetic protocol has been developed for the synthesis of 3-arylindolizine- 1-carboxylates via 1,3-dipolar annulation of 2-(2-nitro-1-arylethyl)malonates with pyridine and subsequent aromatisation in the presence of molecular iodine. The structure of methyl 3-(4-methoxyphenyl)indolizine-1-carboxylate (2a) and methyl 3-iodo-2-(4- nitrophenyl)indolizine-1-carboxylate (2f) was further confirmed by X-ray single crystal analysis. Website
An expedient and green protocol for the Michael addition of malonates, diketones and p-keto esters to the nitrostyrenes
Agarwal, Jyoti,Naganaboina, Ram Tilak,Peddinli, Rama Krishna
, p. 511 - 518 (2013/06/05)
A novel methodology has been developed for the rapid synthesis of functionalized nitroalkanes by the addition of less reactive carbon nucleophiles such as malonate esters, acetylacetone and ethyl acetoacetate to various r/ms-p-nitrostyrenes under solvent-
Immobilization of 1,5,7-triazabicyclo [4.4.0] dec-5-ene over mesoporous materials: An efficient catalyst for Michael-addition reactions under solvent-free condition
Kalita, Pranjal,Kumar, Rajiv
experimental part, p. 250 - 258 (2012/01/05)
Immobilization of 1,5,7-triazabicyclo [4.4.0] dec-5-ene (TBD, a bicylic guanidine base) over mesoporous material like SBA-15 has been found to be an excellent catalyst for Michael-addition of β-nitro styrene with malonate. The reactions were performed und
Highly enantioselective Michael addition of malonates to nitroolefins catalyzed by chiral bifunctional tertiary amine-thioureas based on saccharides
Li, Xiao-Juan,Liu, Kun,Ma, Hai,Nie, Jing,Ma, Jun-An
scheme or table, p. 3242 - 3246 (2009/06/25)
A series of saccharide-derived bifunctional tertiary amine-thioureas for the asymmetric Michael addition reaction have been designed and synthesized. The addition products between malonates and various nitroolefins were obtained in high yields (up to 99%)
An enantioselective Michael addition of malonate to nitroalkenes catalyzed by low loading demethylquinine salts in water
Chen, Fu-Xin,Shao, Cheng,Wang, Quan,Gong, Pin,Zhang, Dong-Yan,Zhang, Bang-Zhi,Wang, Rui
, p. 8456 - 8459 (2008/03/13)
An enantioselective Michael addition of malonate to nitroalkenes is efficiently catalyzed by low loading demethylquinine salts in water; the yield range from 49% to 93% and the ee up to 90%.
