63701-55-3

Basic information

• Product Name: R(+)-BACLOFEN HYDROCHLORIDE
• Synonyms: (+)-r-3-(p-chlorophenyl)-4-aminobutanoicacidhydrochloride;(r)-baclofenmonohydrochloride;beta-(aminomethyl)-4-chloro-,hydrochloride,(r)-benzenepropanoicaci;beta-(aminomethyl)-p-chloro-,hydrochloride,(r)-hydrocinnamicaci;d-baclofenhydrochloride;R(+)-BACLOFEN HYDROCHLORIDE;R(+)-BETA-(AMINOMETHYL)-4-CHLOROBENZENEPROPANOIC ACID HCL;R(+)-BETA-(AMINOMETHYL)-4-CHLOROBENZENEPROPANOIC ACID HYDROCHLORIDE
• CAS NO: 63701-55-3
• Molecular Formula: C₁₀H₁₂ClNO₂*ClH
• Molecular Weight: 250.12
• Product Categories: GABA/Glycine receptor
• Mol File: 63701-55-3.mol
• Article Data: 38

Chemical Properties

• Melting Point: 220～222℃
• Boiling Point: 364.3°C at 760 mmHg
• Flash Point: 174.1°C
• Appearance: white/solid
• Vapor Pressure: 6.01E-06mmHg at 25°C
• Solubility: DMSO: >20 mg/mL
• CAS DataBase Reference: R(+)-BACLOFEN HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: R(+)-BACLOFEN HYDROCHLORIDE(63701-55-3)
• EPA Substance Registry System: R(+)-BACLOFEN HYDROCHLORIDE(63701-55-3)

Safety Data

• Safety Statements: 24/25
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: MW5084350
• Hazardous Substances Data: 63701-55-3(Hazardous Substances Data)

Usage

Uses

R(+)-Baclofen.Hydrochloride is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.

Biochem/physiol Actions

R(+)-Baclofen is a GABAB receptor agonist; more active enantiomer; skeletal muscle relaxant.

InChI:InChI=1/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1

Upstream product

• 188635-62-3 (R)-4-Azido-3-(4-chloro-phenyl)-butyric acid 
• 1042939-73-0 (R)-ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-chlorophenyl)butanoate 
• 104-88-1 4-chlorobenzaldehyde 
• 1679-18-1 4-Chlorophenylboronic acid 
• 940930-58-5 methyl (3S,4R)-4-(4-chlorophenyl)-2-oxopyrrolidine-3-carboxylate 
• 1402406-40-9 (R)-1-chloro-4-(1-nitrobut-3-en-2-yl)benzene 
• 1402406-55-6 (R)-3-(4-chlorophenyl)-4-nitrobutan-1-ol 
• 1020270-34-1 (R)-3-(4-chlorophenyl)-4-nitrobutyraldehyde 
• 776296-22-1 3-(4-chlorophenyl)allyl methyl carbonate 
• 537676-63-4 ethyl (3R)-3-cyano-3-(4-chlorophenyl)propanoate 
• 537676-65-6 ethyl (3S)-3-bromo-3-(4-chlorophenyl)propanoate 
• 1006386-90-8 ethyl (2R,3S)-3-(4-chlorophenyl)-2,3-dihydroxypropionate 
• 70200-14-5 ethyl 3-hydroxy-3-(4-chlorophenyl)propanoate 
• 24393-52-0 ethyl (E)-3-(4-chlorophenyl)prop-2-enoate 

Downstream Products

• 69308-37-8 (R)-baclofen 
• 78184-72-2 3R-1-t-butoxycarbonylamino-3-(4-chlorophenyl)butanoic acid 
• 123632-35-9 (R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 948017-82-1 (R)-4-Amino-3-(4-chloro-phenyl)-butyric acid methyl ester 

Relevant articles and documents

Polysulfonate supported chiral diamine-nickel catalysts: Synthesis and applications

A series of chiral polysulfonate cyclohexyldiamine-Ni(II) catalysts were prepared via sulfur (VI) fluoride exchange click-reactions. The catalysts exhibited good catalytic activity and enantioselectivity in the Michael addition of malonates to nitroalkene

Highly Enantioselective Synthesis of Chiral γ-Lactams by Rh-Catalyzed Asymmetric Hydrogenation

A Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system has been identified for the straightforward asymmetric synthesis of chiral γ-lactams. A variety of NH free α,β-unsaturated lactams bearing a β-aryl or β-alkyl substituent were smoothly hydrogenated to

Enantioselective conjugate hydrocyanation of α,β-unsaturated N-acylpyrroles catalyzed by chiral lithium(I) phosphoryl phenoxide

Enantioselective conjugate hydrocyanation of α,β-unsaturated N-acylpyrroles with the combined use of Me3SiCN, LiCN, and HCN has been developed in the presence of a chiral lithium(I) phosphoryl phenoxide catalyst. This reaction is useful for a v