1378387-81-5 Usage
Description
1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is a complex organic compound characterized by a fluorene ring with a bromine and two fluorine atoms at the 7 and 9 positions, respectively. A chloroethanone group is attached to the fluorene ring, endowing this molecule with unique structural and reactivity properties. It is a versatile building block in organic synthesis and pharmaceutical research, valued for its potential in the development of innovative drugs and materials.
Uses
Used in Organic Synthesis:
1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is used as a key intermediate in organic synthesis for its ability to participate in various chemical reactions, facilitating the creation of a wide range of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is used as a precursor in the development of new drugs. Its unique structure allows for selective functionalization, which is crucial for the synthesis of bioactive compounds with potential therapeutic applications.
Used as a Reagent in Chemical Reactions:
1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone serves as a reagent in a variety of chemical reactions, including those that require the introduction of specific functional groups or the formation of new chemical bonds, contributing to the advancement of chemical research and the discovery of novel chemical entities.
Used in the Synthesis of Complex Organic Molecules:
Due to its specific structural features, 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-ethanone is used as a valuable building block in the synthesis of complex organic molecules, enabling chemists to construct intricate molecular architectures with potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 1378387-81-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,8,3,8 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1378387-81:
(9*1)+(8*3)+(7*7)+(6*8)+(5*3)+(4*8)+(3*7)+(2*8)+(1*1)=215
215 % 10 = 5
So 1378387-81-5 is a valid CAS Registry Number.
1378387-81-5Relevant articles and documents
Preparation method of key intermediate of anti-hepatitis C drug ledipasvir
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, (2019/05/08)
The invention provides a preparation method of a key intermediate 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloroethanone. The method comprises the steps as follows: 2-amino-5-bromobenzoic acid is taken as a raw material, and subjected to diazotization, iodination,synthesis of 5-bromo-2-iodobenzoic acid, methylation, coupling reaction with phenylboronic acid, ester hydrolysis, acyl chlorination,intramolecular Friedel-Crafts alkylation, carbonyl reduction, iodization, fluorination and final reaction with 2-chloro-N-methoxy-N-methylacetamide to prepare the target product. The process adopts easily available starting raw materials, is low in price and free of hazardous process and has mild reaction conditions..
Anti-hepatitis c pharmaceutical intermediates
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, (2018/04/03)
The invention provided a compound represented by the formula I and a method utilizing the compound to prepare an anti hepatitis C drug. The preparation method is simple and economic, and is capable of being applying to industrial production, so the preparation of an anti hepatitis C drug may be achieved. The formula I is represented in the description, wherein the R represents fluorine or hydrogen, and the n is equal to 2 or 3.
Ledipasvir preparation method
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Paragraph 0113; 0115; 0116; 0186; 0255, (2018/05/16)
The invention discloses a Ledipasvir preparation method. The Ledipasvir preparation method includes steps: (1) Ledipasvir intermediate product 1-LD-B preparation; (2) Ledipasvir intermediate product 2-LD-E preparation; (3) Ledipasvir intermediate product 3-LD-F preparation; (4) Ledipasvir intermediate product 4-LD-J preparation; (5) Ledipasvir intermediate product 5-LD-L preparation; (6) Ledipasvir-LD-Q preparation. The Ledipasvir preparation method has advantages of technical maturity and stability, product quality stability, safety and reliability in production process and suitableness for industrial production.
