1256544-03-2Relevant academic research and scientific papers
Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of Racemic β’-Keto-β-Amino Esters via Dynamic Kinetic Resolution
He, Jiayin,Huang, An,Ling, Fei,Wang, Shiliang,Wang, Yifan,Wang, Ze,Zhao, Xianghua,Zhong, Weihui
, p. 4714 - 4719 (2021/09/02)
An iridium/f-diaphos catalytic system for the enantioselective hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution is reported. The desired anti β’-hydroxy-β-amino esters were obtained in moderate to good yields (60–95%) with 72–99% ees and 91:9 to 99:1 drs. This protocol tolerates various functional groups and could be easily conducted on gram scale with lower catalyst loading (TON up to 9100). (Figure presented.).
3-(Hydroxy(phenyl)methyl)azetidin-2-ones obtained via catalytic asymmetric hydrogenation or by biotransformation
Rimoldi, Isabella,Cesarotti, Edoardo,Zerla, Daniele,Molinari, Francesco,Albanese, Domenico,Castellano, Carlo,Gandolfi, Raffaella
experimental part, p. 597 - 602 (2011/06/21)
The catalytic asymmetric reduction of ethyl-2-(benzamidomethyl)-3-oxo- phenylpropanoate was realized with high enantiomeric and diastereoisomeric excesses via biotransformation using whole cells of different yeasts and asymmetric hydrogenation with Ru(II)
Water mediated trapping of active methylene intermediates generated by IBX-induced oxidation of Baylis-Hillman adducts with nucleophiles
Tan, Jia-Neng,Li, Haoquan,Gu, Yanlong
supporting information; experimental part, p. 1772 - 1782 (2011/02/21)
Water proved to be an efficient solvent for oxidation of a Baylis-Hillman adduct with IBX. The generated product, a methylene intermediate, could be trapped in situ by many nucleophiles in water, such as styrenes, β-dicarbonyl compounds, benzamide and les
