125732-13-0Relevant articles and documents
Total Syntheses of Malabaricones B and C via a Cross-Metathesis Strategy
Kundu, Kshama,Nayak, Sandip K.
, p. 1776 - 1782 (2017/06/28)
The malabaricones A-D belong to the class of diarylnonanoids isolated from the Myristicaceae family of plants. Although malabaricone C displayed various interesting biological activities, its isolation remains tedious due to its close chemical similarity to malabaricones A, B, and D. Therefore, development of an efficient synthesis route has become essential to cater to the need of large amounts of malabaricone C for its pharmacological profiling. So far there is only one report of the synthesis of malabaricone C through a lengthy sequence of reactions. We have developed an efficient and short route for the syntheses of malabaricones B and C, which will also provide a convenient access to all other members of the malabaricone family. Synthesis of an important building block, -aryl heptyl bromide, employed in the synthesis was realized by adopting a cross-metathesis reaction as the key step.
Expedient synthesis of novel β-ketoesters from the Mizoroki-Heck coupling of ethyl 3-ethoxyacrylate with aryl and pyridyl halides
Kohrt, Jeffrey T.,Conn, Ed,Maguire, Robert,Wright, Stephen W.,Singer, Robert
, p. 7065 - 7068 (2013/12/04)
It is well known that β-ketoesters are useful intermediates for the synthesis of a range of heterocyclic templates. While there are many useful synthetic methods available to access these intermediates, there are still opportunities for the discovery of useful methodologies for their construction from novel starting materials. In this regard, we report on the discovery of a facile Pd-catalyzed Mizoroki-Heck coupling of ethyl 3-ethoxyacrylate with aryl and heteroaryl halides to form substituted alkoxyacrylates which can be hydrolyzed to form novel aryl and heteroaryl β-ketoesters.
