1257322-08-9

Upstream product

• 25260-60-0 cis-1,4-bis(acetyloxy)but-2-ene 
• 1257321-98-4 dimethyl 2-[2-(phenylsulfonamido)phenyl]malonate 
• 108-59-8 malonic acid dimethyl ester 
• 1493-27-2 ortho-nitrofluorobenzene 
• 26465-37-2 dimethyl 2-(2-nitrophenyl)malonate 
• 86162-61-0 C₁₁H₁₃NO₄ 

Relevant academic research and scientific papers

Regio- and enantioselective synthesis of functionalized tetrahydroquinolines by palladium-catalyzed cyclization of 2- amidophenylmalonates with allylic bisacetates

A palladium-catalyzed cyclization of 2-amidophenylmalonates with allylic bisacetates is described. Tetrahydroquinolines having a vinyl group at the 3- or 2-position were produced, in which the regioselectivity of the resulting products was altered depending on the substituent on the amino group. The product was transformed to the azabicyclo[3.3.1]nonene via the ring-closing metathesis. Enantioselective reactions also successfully proceeded in the presence of (S)-BINAP to give the optically active tetrahydroquinoline with high enantioselectivity.

Highly regioselective synthesis of substituted tetrahydroquinolines by palladium-catalyzed cyclization of substituted 2-amidophenylmalonates with 1,4-diacetoxybut-2-ene

The reaction of 2-amidophenylmalonates with 1,4-diacetoxybut-2-ene in the presence of a palladium catalyst is described. Substituted tetrahydroquinolines having a vinyl group at the 3- or 2-position were synthesized, in which the regioselectivities of the double allylic substitution reactions have been altered depending on the substituent on the amino group.