86162-61-0

Upstream product

• 26465-37-2 dimethyl 2-(2-nitrophenyl)malonate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 1210801-41-4 dimethyl 2-[2-(4-methylphenylsulfonamido)phenyl]malonate 
• 1257322-07-8 dimethyl-1-(4-methylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate 
• 1257322-08-9 dimethyl-1-(phenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate 
• 1412902-24-9 dimethyl 1-(4-nitrophenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate 
• 1412902-25-0 dimethyl 1-(3,5-dimethylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate 
• 1257322-10-3 1-benzyl 4,4-dimethyl 3-vinyl-2,3-dihydroquinoline-1,4,4-tricarboxylate 
• 1257322-11-4 1-benzyl 4,4-dimethyl 2-vinyl-2,3-dihydroquinoline-1,4,4-tricarboxylate 
• 1257321-98-4 dimethyl 2-[2-(phenylsulfonamido)phenyl]malonate 
• 1257321-99-5 dimethyl 2-[2-(naphthalene-2-sulfonamido)phenyl]malonate 
• 1412902-19-2 dimethyl 2-[2-(4-nitrophenylsulfonamido)phenyl]malonate 
• 1412902-20-5 dimethyl 2-[2-(3,5-dimethylphenylsulfonamido)phenyl]malonate 
• 1412902-21-6 dimethyl 2-[2-(4-methoxyphenylsulfonamido)phenyl]malonate 
• 1412902-22-7 dimethyl 2-[2-(4-(trifluoromethyl)phenylsulfonamido)phenyl]malonate 
• 1412902-23-8 dimethyl 2-[2-(4-cyanophenylsulfonamido)phenyl]malonate 

Relevant academic research and scientific papers

Asymmetric triple relay catalysis: Enantioselective synthesis of spirocyclic indolines through a one-pot process featuring an asymmetric 6π electrocyclization

A rare example of a one-pot process that involves asymmetric triple relay catalysis is reported. The key step is an asymmetric [1,5] electrocyclic reaction of functionalized ketimines. The substrates for this process were obtained in situ in a two-step process that involved the hydrogenation of nitroarenes with a Pd/C catalyst to yield aryl amines and their subsequent coupling with isatin derivatives in a Bronsted acid catalyzed ketimine formation reaction. The electrocycli-zation was catalyzed by a bifunctional chiral Bronsted base/ hydrogen bond donor catalyst. The one-pot process gave the desired products in good yields and with excellent enantiose-lectivity.

Regio- and enantioselective synthesis of functionalized tetrahydroquinolines by palladium-catalyzed cyclization of 2- amidophenylmalonates with allylic bisacetates

A palladium-catalyzed cyclization of 2-amidophenylmalonates with allylic bisacetates is described. Tetrahydroquinolines having a vinyl group at the 3- or 2-position were produced, in which the regioselectivity of the resulting products was altered depending on the substituent on the amino group. The product was transformed to the azabicyclo[3.3.1]nonene via the ring-closing metathesis. Enantioselective reactions also successfully proceeded in the presence of (S)-BINAP to give the optically active tetrahydroquinoline with high enantioselectivity.

Diphosphine-catalyzed mixed double-michael reaction: A unified synthesis of lndolines, Dihydropyrrolopyridines, Benzimidazolines, Tetrahydroquinolines, Tetrahydroisoquinolines, Dihydrobenzo-1,4-oxazines, and Dihydrobenzo-3,1- oxazines

(Figure Presented) Seven different types of benzannulated N-heterocycles-indolines, dihydropyrrolopyridlnes, benzimidazolines, dihydrobenzo-3,1-oxazines, benzomorpholines, tetrahydroquinolines, and tetrahydroisoquinolines-can be obtained from simple dinuc