1257321-98-4

Upstream product

• 86162-61-0 C₁₁H₁₃NO₄ 
• 98-09-9 benzenesulfonyl chloride 
• 26465-37-2 dimethyl 2-(2-nitrophenyl)malonate 
• 108-59-8 malonic acid dimethyl ester 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 1257322-08-9 dimethyl-1-(phenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate 

Relevant academic research and scientific papers

Regio- and enantioselective synthesis of functionalized tetrahydroquinolines by palladium-catalyzed cyclization of 2- amidophenylmalonates with allylic bisacetates

A palladium-catalyzed cyclization of 2-amidophenylmalonates with allylic bisacetates is described. Tetrahydroquinolines having a vinyl group at the 3- or 2-position were produced, in which the regioselectivity of the resulting products was altered depending on the substituent on the amino group. The product was transformed to the azabicyclo[3.3.1]nonene via the ring-closing metathesis. Enantioselective reactions also successfully proceeded in the presence of (S)-BINAP to give the optically active tetrahydroquinoline with high enantioselectivity.