1257395-67-7

Basic information

• Product Name: 2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid
• Synonyms: 2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid
• CAS NO: 1257395-67-7
• Molecular Weight: 543.593
• Mol File: 1257395-67-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid(1257395-67-7)
• EPA Substance Registry System: 2-methyl-2-(6-(4-methyl-1-(4-(trifluoromethyl)piperidin-1-yl)pentyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)propanoic acid(1257395-67-7)

Safety Data

• Hazardous Substances Data: 1257395-67-7(Hazardous Substances Data)

Upstream product

• 38136-29-7 4-methylvaleroyl chloride 
• 149490-75-5 2-(3-hydroxy-phenyl)-2-methyl-propionic acid methyl ester 

Relevant articles and documents

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach

Starting from literature examples of nonsteroidal anti-inflammatory drugs (NSAIDs)-type carboxylic acid γ-secretase modulators (GSMs) and using a scaffold design approach, we identified 4-aminomethylphenylacetic acid 4 with a desirable γ-secretase modulation profile. Scaffold optimization led to the discovery of a novel chemical series, represented by 6b, having improved brain penetration. Further SAR studies provided analog 6q that exhibited a good pharmacological profile. Oral administration of 6q significantly reduced brain Aβ42 levels in mice and rats.