125796-46-5Relevant academic research and scientific papers
Iron-catalyzed regioselective alkylation of 1,4-quinones and coumarins with functionalized alkyl bromides
Li, Dengke,Shen, Xianfu
supporting information, p. 750 - 754 (2020/02/11)
A simple and efficient Fe-catalyzed regioselective alkylation of 1,4-quinones and coumarins, using functionalized alkyl bromides as alkylating reagents, has been developed. The reaction proceeds under mild conditions with the addition of alkyl bromides to a wide range of 1,4-quinone and coumarin derivatives with a broad substrate scope and wide functional group tolerance to provide the products in good yields. Further application of these strategies could be extended to important biologically active antimalarial lead drugs, such as plasmodione on a gram scale in a single step for medicinal purposes.
Copper-catalyzed regioselective cross-dehydrogenative coupling of coumarins with benzylic Csp3-H bonds
Zhou, Shi-Liu,Guo, Li-Na,Duan, Xin-Hua
, p. 8094 - 8100 (2015/02/02)
A new copper-catalyzed regioselective cross-dehydrogenative coupling of coumarins with benzylic Csp3-H bonds has been developed. This reaction provides direct access to a wide range of 3-benzylcoumarins in moderate to good yields. The protocol was also extended successfully to other heterocyclic compounds, such as quinolinones.
A One Step General Synthesis of 3-Benzylcoumarins
Deshmukh, Sanjay Y.,Kelkar, Shriniwas L.,Wadia, Murzban S.
, p. 855 - 863 (2007/10/02)
Reaction od a preformed complex of the amides (2a-c) and POCl3 with substituted salicylaldehydes yielded 3-benzylcoumarins in one step and in good yields.
A CONVINIENT SYNTHESIS OF 3-BENZYL-4-SUBSTITUTED COUMARINS AND THEIR BENZO DERIVATIVES
Britto, Nirmala,Gore, Vinayak G.,Mali, R. S.,Ranade, A. C.
, p. 1899 - 1910 (2007/10/02)
It is reported in the literature that alkylation of simple (unsubstituted) phosphorane with alkyl halide in ethyl acetate leads to equimolar mixture of alkylated phosphorane and salt of the unsubstituted phosphorane.Here we report exclusive formation of a
