1258792-41-4

Upstream product

• 551-93-9 2-aminoacetophenone 
• 78396-00-6 2-aminochalcone 
• 25410-99-5 3-phenylquinolin-4(1H)-one 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 124856-99-1 2'-Aminochalcone Epoxide 
• 696-62-8 para-iodoanisole 
• 23112-60-9 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid 
• 247940-06-3 CyJohnPhos 
• 166330-10-5 bis[2-(diphenylphosphino)phenyl] ether 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 36081-66-0 2'-bromo-2-phenylacetophenone 
• 1258792-30-1 3-(2-bromophenyl)-3-oxo-2-phenylpropanal 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Azaisoflavones: Synthesis, antimicrobial evaluation and binding affinity with DNA gyrase

Antimicrobial potency of azaisoflavones has been evaluated in vitro against nine bacterial and two fungal strains, respectively. The requisite azaisoflavones are conveniently synthesized in three steps, with the key step being the super acid catalyzed tandem reaction. The biological results reveal that out of twelve compounds screened, 3 compounds (5a, 5j and 5l) exhibited comparable activities against the standard drugs and demonstrated activities at μM concentration. In addition, molecular docking revealed that compound 5a as the most potent by showing a least binding energy of -5.99 kcal/mol with DNA gyrase receptor compared to other compounds.

Palladium-catalyzed decarboxylative coupling of quinolinone-3-carboxylic acids and related heterocyclic carboxylic acids with (Hetero)aryl halides

An efficient and practical decarboxylative cross-coupling reaction of quinolin-4(1H)-one 3-carboxylic acids with (hetero)aryl halides has been established. Under a bimetallic system of PdBr2 and silver carbonate, the protocol proved to be general, and a variety of 3-(hetero)aryl 4-quinolinones and related heterocycles, such as 3-aryl-1,8-naphthyridin-4(1H)- ones, 3-arylcoumarins, 3-arylquinolin-2(1H)-ones, and 2-arylchromones, can be prepared in good to excellent yields.

Metal-free intramolecular amination: One-pot tandem synthesis of 3-substituted 4-quinolones

3-Substituted 4-quinolones were synthesized using a one-pot metal-free strategy in moderate to quantitative yields. Carried out in dimethylsulfoxide (DMSO) via a sequential addition of materials, the methodology is tolerant of a wide range of functional groups and applicable to library synthesis.