1259319-03-3

Basic information

• Product Name: 1,3-bis(2′,4′,6′-trimethylphenyl)imidazolium perchlorate
• Synonyms: 1,3-bis(2′,4′,6′-trimethylphenyl)imidazolium perchlorate
• CAS NO: 1259319-03-3
• Molecular Weight: 404.894
• Mol File: 1259319-03-3.mol

Chemical Properties

• CAS DataBase Reference: 1,3-bis(2′,4′,6′-trimethylphenyl)imidazolium perchlorate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(2′,4′,6′-trimethylphenyl)imidazolium perchlorate(1259319-03-3)
• EPA Substance Registry System: 1,3-bis(2′,4′,6′-trimethylphenyl)imidazolium perchlorate(1259319-03-3)

Safety Data

• Hazardous Substances Data: 1259319-03-3(Hazardous Substances Data)

Upstream product

• 56222-36-7 N,N'-bis(2,4,6-trimethylphenyl)ethanediimine 
• 64-19-7 acetic acid 

Relevant articles and documents

Synthesis, Antitumor Activity, and Docking Study of 1,3-Disubstituted Imidazolium Derivatives

A series of 1,3-disubstituted imidazolium salts were synthesized through a convenient synthetic approach based on the reaction of 1,4-diazabuta-1,3-dienes with HClO4. Their antitumor activity was evaluated in vitro against a number of human cancer cells. 1,3-Bis[(3,5-bis(trifluoromethyl)phenyl]imidazolium perchlorate turned out to be the most active against A549 and MCF-7 cancer cell lines with IC50 values of 5.24 and 4.21 μM, respectively. The results of structure–activity relationship study indicated that substituents on the imidazole derivatives play an important role in their cytotoxic activities. Finally, molecular docking of some tested compounds was carried out in order to investigate their binding pattern with the CDK2.

Revelation from the Reaction of 1,4-Diazabutadiene with Perchloric Acid: An Approach to the Synthesis of Imidazolium Perchlorates

The reactions of 1,4-diazabutadienes 1 with HClO4were studied in detail. The final products obtained were not the hydroperchlorates of 1 but imidazolium perchlorates 2 or 3. A possible reaction process is postulated on the basis of the isolation of the intermediate 2-iminomethylimidazolium salt 4. The factors influencing the conversion of 4 to the imidazolium perchlorates 2 and 3 were discussed with regard to the electronic and steric effects of the N-substituents. This reaction can serve as an approach for the synthesis of imidazolium derivatives.