150542-06-6

Basic information

• Product Name: α,α,α-iodinefluoroacetophenone
• Synonyms: α,α,α-iodinefluoroacetophenone
• CAS NO: 150542-06-6
• Molecular Weight: 282.028
• Mol File: 150542-06-6.mol

Chemical Properties

• CAS DataBase Reference: α,α,α-iodinefluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: α,α,α-iodinefluoroacetophenone(150542-06-6)
• EPA Substance Registry System: α,α,α-iodinefluoroacetophenone(150542-06-6)

Safety Data

• Hazardous Substances Data: 150542-06-6(Hazardous Substances Data)

Upstream product

• 86340-78-5 2,2-difluoro-1-phenyl-1-trimethylsiloxyethene 
• 384-67-8 2-chloro-2,2-difluoroacetophenone 
• 1259998-89-4 2,2,4,4,4-pentafluoro-3,3-dihydroxy-1-phenylbutan-1-one 
• 41463-86-9 4,4,4-trifluoro-3-hydroxy-1-phenylbut-2-en-1-one 
• 98-86-2 acetophenone 

Downstream Products

• 169826-95-3 1,1-Difluoro-3-iodooctyl phenyl ketone 
• 156479-77-5 phenyl α,α-difluoro-γ-iodoheptyl ketone 
• 150542-12-4 2,2-Difluoro-4-iodo-1-phenyl-1,7-octanedione 
• 155535-01-6 N,N-Dimethyl-4-benzoyl-4,4-difluoro-2-iodobutanamide 
• 156575-49-4 Methyl 4,4-difluoro-2-iodo-4-benzoylbutanoate 
• 395-01-7 2,2-difluoro-1-phenylethanone 
• 155534-91-1 ethyl 2-iodo-4,4-difluoro-4-benzoyl butyrate 
• 169826-96-4 2,2-Difluoro-12-hydroxy-4-iodo-1-phenyl-dodecan-1-one 
• 172289-46-2 2,2-difluoro-1-phenylhexane-1,5-dione 

Relevant articles and documents

Nickel-Catalyzed Aminofluoroalkylation of Alkenes: Access to Difluoroalkylated N-Containing Heterocyclic Compounds

A nickel-catalyzed aminofluoroalkylative cyclization of unactive alkenes with iododifluoromethyl ketones was developed to construct versatile difluoroalkylated Nitrogen-containing heterocycles including aziridines, pyrrolidines and piperidines in moderate to high yields. This method features a broad substrate scope and has been demonstrated on gram scale.

Copper-Catalyzed Three-Component Reactions of 2-Iodo-2,2-difluoroacetophenones, Alkynes, and Trimethylsilyl Cyanide

A Cu(I)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes, and TMSCN is described. The reaction provided a facile method for the synthesis of difluoroacyl-substituted nitriles, which might be served as potentially useful fluo

A accompanies two fluorine substituted tetrahydronaphthalene ketone compound and its preparation method

The invention provides a accompanies two fluorine substituted tetrahydronaphthalene ketone compound and its preparation method. The accompanies two fluorine substituted tetrahydronaphthalene ketone compound, characterized in that its structure such as for

Beta-iododifluoroacetone derivative and preparation method thereof

The invention relates to a beta-iododifluoroacetone derivative and a preparation method thereof. The preparation method comprises the following steps: dissolving an iododifluoroketone compound raw material and an olefin raw material in a solvent, then add

Palladium-Catalyzed Benzodifluoroalkylation of Alkynes: A Route to Fluorine-Containing 1,1-Diarylethylenes

A palladium(0)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes and arylboronic acids is introduced for the synthesis of 1-benzoyldifluoromethyl-2,2-diphenylethylenes in good yields and with excellent stereoselectivity. The

Synthesis of α,α-difluorobenzoyl oxygen heterocycles via the radical reaction of 2-iodo-2,2-difluoroacetophenones with unsaturated acids or unsaturated alcohols

A convenient and facile method for the direct synthesis of α,α-difluorobenzoyl lactones or cyclic ethers via the radical cyclization reaction of 2-iodo-2,2-difluoroacetophenone with unsaturated acids or alcohols was reported.

Synthesis of difluoroalkyl-γ-butyrolactones from iododifluoromethyl ketones and 4-pentenoic acids

A convenient and efficient approach for difluoroalkyl-containing γ-butyrolactones via the radical addition reaction of iododifluoromethyl ketones with 4-pentenoic acids initiated by AIBN in CH3CN at 60 °C was reported. Various difluoroalkyl-containing δ-valerolactones were also synthesized under this reaction conditions.

Synthesis of α,α-Difluoro-Functionalized Ketones

In the presence of a catalytic amount of tetrakis(triphenylphosphine)palladium , iododifluoromethyl alkyl and phenyl ketones 1 react with alkenes to give the corresponding α,α-difluoro-γ-iodo ketones in high yields at room temperature either neat or in hexane at 60 deg C.A variety of functional groups, such as alkyl, trimethylsilyl, hydroxy, epoxy, ketone, and ester, are tolerated under the reaction conditions.The reaction can be completely suppressed by a radical inhibitor, di-tert-butyl nitroxide or hydroquinone.A ring closure reaction occurs when 1 reacts with diethyl diallylmalonate in the presence of a catalytic amount of Pd(PPh3)4.Under UV irradiation, the reaction of 1 with diallyl ether gives a tetrahydrofuran derivative.All these results are consistent with a radical chain mechanism initiated by single electron transfer from Pd(PPh3)4 to 1.In the presence of a catalytic amount of nickel dichloride hexahydrate, the iodine in the 1:1 addition adducts is readily reduced by zinc in moist THF under mild conditions to give the corresponding α,α-difluoro ketones in high yields.A one-pot addition-reduction reaction has been developed for the synthesis of α,α-difluoroketones without the isolation of the 1:1 addition adducts, which provides a new, efficient, and practical method for the preparation of a variety of α,α-difluorofunctionalized ketones.

Synthesis of Aryl &α,&α-Difluoroalkyl Ketones as Potent Inhibitors of Cholesterol Esterase

Aryl α,α-difluoroalkyl ketones were synthesized from the reaction of ethyl α,α-difluoroacylate with aryl lithium at -78 deg C or from the coupling of aryl iododifluoromethyl ketone with 1-alkene in the presence of teterakis(triphenylphisphine)palladium(0).These compounds were potent inhibitors of pancreatic cholesterol esterase with Ki values in the range 15 μM-20 nM.