1260219-53-1Relevant articles and documents
Salicylato titanocene complexes as cooperative organometallic lewis acid and bronsted acid catalysts for three-component mannich reactions
Wu, Ya,Chen, Chun,Jia, Gai,Zhu, Xuyang,Sun, Huaming,Zhang, Guofang,Zhang, Weiqiang,Gao, Ziwei
, p. 8530 - 8535 (2014)
A binary acid system has been developed that features an air-stable organometallic precursor, titanocene dichloride, and simple organic cooperative Bronsted acids, which allowed for mild and highly efficient Mannich reactions of both aryl and alkyl ketones with excellent yields and satisfactory diastereoselectivity. Mechanistic studies, including 1H NMR titration, X-ray structure analyses as well as isolation of catalytically active species, elucidated the dramatic synergistic effects of this new binary acid system.
Polyacrylic acid heterogeneous catalytic preparation of β-amino carbonyl compounds method
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Paragraph 0013; 0054-0057, (2020/05/05)
The invention discloses a method for preparing a beta-amino carbonyl compound through polyacrylic acid heterogeneous catalysis. Under the polyacrylic acid catalysis condition, aldehyde, arylamine, cyclohexanone or acetone reacts directly to obtain the beta-amino carbonyl compound. Solvents are not needed to be added, used catalysts are cheap, non-toxic, stable to air, simple to operate, mild in reaction condition, short in reaction time and high in atom economy, a product is only needed to be dissolved and separated from a reactor with ethyl acetate after the reaction is finished, the catalysts can be repeatedly used, and experimental results show that the catalytic activity of the catalysts is still high after the catalysts are repeatedly used for five times, the yield of the product is basically unchanged, and the method has a wide application prospect in synthesis of the beta-amino carbonyl compound.
Cooperative catalysis of p-aminophenol and titanocene dichloride in direct Mannich reactions with acetone
Zhu, Xuyang,Chen, Chun,Yu, Binxun,Zhang, Guofang,Zhang, Weiqiang,Gao, Ziwei
, p. 1832 - 1834 (2015/01/16)
A new binary acid system featuring an air stable organometallic precursor, titanocene dichloride and a simple Bronsted acidbase compound, was developed. The new catalyst system allowed for mild and highly efficient direct three-component Mannich reactions of both aryl ketones and alkyl ketones, in particular, acetone and its derivatives with excellent yields. Mechanistic study elucidated the dramatic synergistic effect of the new binary acid system.
A novel trypsin-catalyzed three-component mannich reaction
Chai, She-Jie,Lai, Yi-Feng,Zheng, Hui,Zhang, Peng-Fei
experimental part, p. 2231 - 2236 (2011/02/16)
We found that the trypsin from hog pancreas displayed high activity to promote three-component Mannich reaction of aromatic aldehydes, aromatic amines, and acetone with moderate-to-excellent yields. The reaction tolerates a great range of substrates and e
