1261852-14-5

Basic information

• Product Name: 2-(bromomethyl)-4-fluoro-1-iodobenzene
• Synonyms: 2-(bromomethyl)-4-fluoro-1-iodobenzene
• CAS NO: 1261852-14-5
• Molecular Weight: 314.924
• Mol File: 1261852-14-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(bromomethyl)-4-fluoro-1-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(bromomethyl)-4-fluoro-1-iodobenzene(1261852-14-5)
• EPA Substance Registry System: 2-(bromomethyl)-4-fluoro-1-iodobenzene(1261852-14-5)

Safety Data

• Hazardous Substances Data: 1261852-14-5(Hazardous Substances Data)

Usage

Description

2-(bromomethyl)-4-fluoro-1-iodobenzene is a chemical compound characterized by the molecular formula C7H5BrFI. It is a substituted benzene derivative featuring a bromomethyl group at the 2-position, and fluorine and iodine atoms at the 4 and 1 positions, respectively. 2-(bromomethyl)-4-fluoro-1-iodobenzene is recognized for its versatile reactivity and unique combination of functional groups, which makes it a valuable building block in the synthesis of more complex organic compounds.

Uses

Used in Pharmaceutical Synthesis:
2-(bromomethyl)-4-fluoro-1-iodobenzene is utilized as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its diverse functional groups allow for the creation of a wide range of medicinal compounds with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical sector, 2-(bromomethyl)-4-fluoro-1-iodobenzene serves as a key intermediate in the production of pesticides and other crop protection agents. Its reactivity and structural features contribute to the development of effective and targeted agrochemicals.
Used in Research and Development:
2-(bromomethyl)-4-fluoro-1-iodobenzene is also employed in the research and development of new chemical processes and materials. Its unique properties make it a useful tool for exploring novel reactions and syntheses, potentially leading to the discovery of new compounds with various applications across different industries.

Upstream product

• 52548-63-7 5-fluoro-2-iodobenzoic acid 
• 877264-43-2 (5-fluoro-2-iodophenyl)methanol 
• 66256-28-8 4-fluoro-1-iodo-2-methylbenzene 

Downstream Products

• 1401967-34-7 4-fluoro-1-iodo-2-(methoxymethyl)benzene 
• 842167-55-9 {2-[4-fluoro-2-(methoxymethyl)phenyl]ethynyl}trimethylsilane 

Relevant articles and documents

Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)-H Arylation with a Transient Directing Group

Methylene-selective C-H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) catalysis. We report a Pd(II)-catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)-H arylation of ketones. The reaction utilizes glycine as a transient directing group and a 2-pyridone ligand, which may govern the methylene selectivity by making intimate molecular associations with the substrate during concerted metalation-deprotonation. This reaction is shown to be highly selective for intramolecular methylene C(sp3)-H arylation, thus enabling sequential C(sp3)-H functionalization.

CuSO4-Catalyzed dual annulation to synthesize O, S or N-containing tetracyclic heteroacenes

In this work, CuSO4 is utilized as a practical redox catalyst for tandem dual annulation in the synthesis of indole-fused tetracyclic heteroacenes, which are important skeletons in both medicinal chemistry and materials chemistry. The preparation of such skeletons in a convenient and efficient manner is in high demand. This method realizes the modular synthesis of benzofuro-, benzothieno-, and indoloindoles from abundant feedstocks such as 2-halobenzyl halides and nitrile derivatives in up to 99% yields, providing a rapid access to diverse indole-fused heteroacenes with biological or optoelectronic properties.

A concise synthesis of chiral indanes as α1A adrenoceptor partial agonists

The synthesis of a series of chiral indanes with reported α1A partial agonist activity is outlined, applying a rhodium catalysed cyclisation for template construction. This method was extended to the asymmetric synthesis of lead compound PF-037