52548-63-7

Usage

Uses

Used in Organic Synthesis:
5-Fluoro-2-iodobenzoic acid is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and reactivity allow for the formation of complex molecules that are otherwise difficult to obtain, making it a valuable asset in the field of organic chemistry.
Used in Pharmaceutical Drug Discovery:
In the pharmaceutical industry, 5-Fluoro-2-iodobenzoic acid is employed as a starting material for the development of new drugs. Its potential to form diverse chemical structures makes it a promising candidate for the creation of novel therapeutic agents, particularly in the areas of cancer treatment and other diseases.
Used in Materials Science:
5-Fluoro-2-iodobenzoic acid is utilized in the development of advanced materials with unique properties. Its incorporation into the molecular structure of these materials can lead to enhanced performance, such as improved stability, reactivity, or selectivity, which is crucial in various applications, including catalysis and sensing.
Used in Chemical Research:
5-Fluoro-2-iodobenzoic acid is used as a research tool in academic and industrial laboratories. Its reactivity and structural features make it an ideal compound for studying reaction mechanisms, exploring new synthetic routes, and understanding the properties of related compounds. This knowledge can be applied to the development of new materials, drugs, and other chemical products.

InChI:InChI=1/C7H4FIO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)

Upstream product

• 326-65-8 N-(4-fluoro-2-methylphenyl)acetamide 
• 52548-59-1 10-chloro-2-fluoro-10,11-dihydro-dibenzo[b,f]thiepine 
• 52548-62-6 2-amino-5-fluorobenzoic acid hydrochloride 
• 110-16-7 maleic acid 
• 49579-56-8 2-acetamido-5-fluorobenzoic acid 
• 446-08-2 2-amino-5-fluorobenzoic acid 

Downstream Products

• 82341-39-7 2-(4-Ethoxycarbonyl-phenoxy)-5-fluoro-benzoic acid 
• 134987-41-0 5-fluoro-2-(3-methoxyphenylthio)benzoic acid 
• 52548-64-8 5-fluoro-2-(phenylthio)benzoic acid 
• 52548-66-0 3-fluoro-6-(phenylthio)-benzyl chloride 
• 52548-65-9 3-fluoro-6-(phenylthio)-benzyl alcohol 
• 56096-92-5 2-(4-Chlorphenylthio)-5-fluorbenzylalkohol 
• 56096-94-7 2-(4-Chlorphenylthio)-5-fluorbenzylchlorid 
• 56096-96-9 [2-(4-Chloro-phenylsulfanyl)-5-fluoro-phenyl]-acetonitrile 
• 56096-98-1 [2-(4-Chloro-phenylsulfanyl)-5-fluoro-phenyl]-acetic acid 
• 52548-67-1 3-fluoro-6-(phenylthio)-phenylacetonitrile 
• 52548-68-2 3-fluoro-6-(phenylthio)-phenylacetic acid 
• 877264-43-2 (5-fluoro-2-iodophenyl)methanol 
• 1175627-99-2 (5-fluoro-2-iodophenyl)(2-hydroxy-5-methylphenyl)methanone 
• 1262193-15-6 (2,4,6-trimethylbenzene-1,3,5-triyl)tris(methylene) tris(5-fluoro-2-iodobenzoate) 

Relevant academic research and scientific papers

Preparation method of lorlatinib intermediate compound

The invention relates to a preparation method of a lorlatinib intermediate compound. 4-fluoroacetanilide is taken as a raw material and carry out visible light Fries rearrangement in the presence of avisible light catalyst and visible light to obtain an i

Heterocyclic Compound

The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the prophylaxis or treatment of sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Copper-Catalyzed C(sp3)-S Bond and C(sp2)-S Bond Cross-Coupling of 2-(2-Iodobenzoyl) Substituted or 2-(2-Iodobenzyl) Substituted 1,2,3,4-Tetrahydroisoquinolines with Potassium Sulfide: Synthesis of Isoquinoline-Fused 1,3-Benzothiazine Scaffolds

The sulfuration reaction of 2-(2-iodobenzoyl) substituted, or 2-(2-iodobenzyl) substituted 1,2,3,4-tetrahydroisoquinolines with potassium sulfide proceeded in the presence of copper catalysts to give tetrahydroisoquinoline-fused 1,3-benzothiazine scaffolds in moderate to appropriate yields. This protocol provided an efficient and simple strategy to construct the corresponding benzothiazine derivatives via formation of C(sp3)-S bond and C(sp2)-S bond, which the C-S bonds formed via different routes in this reaction (traditional cross-coupling reaction via the cleavage of C-I bond and oxidative cross-coupling reaction via C(sp3)-H bond functionalization).

Preparation method of 1-(5-fluoro-2-iodophenyl)ethanone

The invention relates to a preparation method of 1-(5-fluoro-2-iodophenyl)ethanone.According to the method, 2-amino-5-fluorobenzoic acid and 5-fluoro-2-iodobenzoic acid react to prepare the final product 1-(5-fluoro-2-iodophenyl)ethanone.The method is sim

Lewis Acid Catalyzed Formal Intramolecular [3 + 3] Cross-Cycloaddition of Cyclopropane 1,1-Diesters for Construction of Benzobicyclo[2.2.2]octane Skeletons

A novel Lewis acid catalyzed formal intramolecular [3 + 3] cross-cycloaddition (IMCC) of cyclopropane 1,1-diesters has been successfully developed. This supplies an efficient and conceptually new strategy for construction of bridged bicyclo[2.2.2]octane skeletons. This [3 + 3]IMCC could be run up to gram scale and from easily prepared starting materials. This [3 + 3]IMCC, together with our previously reported [3 + 2]IMCC strategy, can afford either the bicyclo[2.2.2]octane or bicyclo[3.2.1]octane skeletons from the similar starting materials by regulating the substituents on vinyl group.

Direct carbocyclizations of benzoic acids: Catalyst-controlled synthesis of cyclic ketones and the development of tandem aHH (acyl Heck-Heck) reactions

The formation of exo-methylene indanones and indenones from simple ortho-allyl benzoic acid derivatives has been developed. Selective formation of the indanone or indenone products in these reactions is controlled by choice of ancillary ligand. This new process has a low environmental footprint as the products are formed in high yields using low catalyst loadings, while the only stoichiometric chemical waste generated from the reactants in the transformation is acetic acid. The conversion of the active cyclization catalyst into the Hermman-Beller palladacycle was exploited in a one-pot tandem acyl Heck-Heck (aHH) reaction, and utilized in the synthesis of donepezil. Carboxylic acids in aHH: Simple ortho-allyl benzoic acid derivatives have been utilized in an acyl Heck (aH) reaction to selectively form indanones and indenones. The conversion of the active cyclization catalyst into the Hermman-Beller palladacycle was exploited in a one-pot tandem acyl Heck-Heck (aHH) reaction to form two sp 2-sp2 bonds of (E)-trisubstituted olefins.

MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Palladium-catalyzed insertion of N-tosylhydrazones for the synthesis of isoindolines

Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with α,β-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration of a wide range of functional groups, (2) easy to handle and with mild conditions, (3) enriches the isoindoline family, (4) two new bonds form in one step.

IMIDAZOPYRIMIDINONES AND USES THEREOF

The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.

Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.