842167-55-9Relevant academic research and scientific papers
A concise synthesis of chiral indanes as α1A adrenoceptor partial agonists
Roberts, Lee R.,Corbett, Matthew S.,Fussell, Steven J.,Hitzel, Laure,Jessiman, Alan S.,Mason, Helen J.,Osborne, Rachel,Ralph, Michael J.,Stennett, Adam S.D.,Wheeler, Simon,Storer, R. Ian
supporting information, p. 6546 - 6550 (2015/11/09)
The synthesis of a series of chiral indanes with reported α1A partial agonist activity is outlined, applying a rhodium catalysed cyclisation for template construction. This method was extended to the asymmetric synthesis of lead compound PF-037
Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists
Roberts, Lee R.,Bryans, Justin,Conlon, Kelly,McMurray, Gordon,Stobie, Alan,Whitlock, Gavin A.
scheme or table, p. 6437 - 6440 (2009/10/01)
A novel series of central nervous system (CNS) penetrant indane 2-imidazoles have been identified as potent, partial agonists of the α1A adrenergic receptor, having good selectivity over the α1B, α1D and α2 sub-
Copper-catalyzed allylations of zirconocene intermediates generated from o-alkenyl or o-alkynylbenzyl ether derivatives and zirconocene-butene complex
Ikeuchi, Yutaka,Taguchi, Takeo,Hanzawa, Yuji
, p. 756 - 759 (2007/10/03)
(Chemical Equation Presented) o-Alkenyl or alkynyl benzylzirconocene intermediate, which was readily generated by the reaction of 2-alkoxymethyl-styrene or 2-alkoxymethyl-1-(trimethylsilylethynyl)-benzene derivative with zirconocene-butene complex (Negishi reagent, "Cp 2Zr"), reacted with allyl or propargyl halides in the presence of a catalytic amount of CuCl to give allylation or allenylation products. Conversion to Dane's diene, which is a key intermediate for estrone synthesis, was efficiently carried out by enyne olefin metathesis of the allylation products.
