NMS-P₅₁₅

Base Information

Chemical Name:NMS-P₅₁₅
CAS No.:1262395-13-0
Molecular Formula:C₂₁H₂₉N₃O₂
Molecular Weight:355.48
Hs Code.:

Synonyms:NMS-P₅₁₅

Suppliers and Price of NMS-P₅₁₅

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of NMS-P₅₁₅

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of NMS-P₅₁₅

There total 18 articles about NMS-P₅₁₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1262396-58-6
(1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

: 1262395-13-0
NMS-P₅₁₅

Guidance literature:: With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; for 16h; Inert atmosphere;

Reference yield:

: 1262395-10-7
(±)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide

: 1262395-13-0
NMS-P₅₁₅

: 1262395-17-4
(1R)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide

Guidance literature:: With Chiralcel OD; In methanol; ethanol; hexane; Purification / work up; Resolution of racemate;

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1262395-13-0
NMS-P₅₁₅

: 1262395-17-4
(1R)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: titanium tetrachloride; triethylamine / dichloromethane / 48 h / Inert atmosphere; Reflux

2.1: sodium cyanoborohydride / dichloromethane; methanol / 20 °C / Inert atmosphere

3.1: toluene / 6 h / Reflux

4.1: hydrogenchloride / water / 3 h / Reflux

5.1: potassium carbonate; pyridine / methanol / 4 h / 20 °C

6.1: N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 2 h / 50 °C

8.1: sodium acetate / dichloromethane; methanol / 5 h / 20 °C

8.2: 20 °C

9.1: Chiralcel OD / methanol; hexane; ethanol / Resolution of racemate

With pyridine; hydrogenchloride; N-hydroxybenzotriazole ammonium salt; sodium acetate; titanium tetrachloride; sodium cyanoborohydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3.1: |Diels-Alder Cycloaddition;
DOI:10.1021/acsmedchemlett.8b00569