12626-17-4 Usage
Description
This tremorgenic alkaloid is highly toxic and is elaborated by Aspergillus
jurnigatus. The structure given above has been determined from X-ray crystallography. The crystals are orthorhombic with space group P2 1212 1, a = 14.771,
b = 24.925 and c = 7.321 A with Z = 4. The absolute configuration is based
upon that of L( - )-proline formed by acid hydrolysis of the alkaloid.
Definition
ChEBI: An organic heteropentacyclic compound that is a mycotoxic indole alkaloid produced by several fungi via a tryptophan-proline diketopiperazine intermediate.
References
Yamazaki et al., Tetrahedron Lett., 27 (1975)
Check Digit Verification of cas no
The CAS Registry Mumber 12626-17-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,6,2 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 12626-17:
(7*1)+(6*2)+(5*6)+(4*2)+(3*6)+(2*1)+(1*7)=84
84 % 10 = 4
So 12626-17-4 is a valid CAS Registry Number.
InChI:InChI=1/C27H33N3O5/c1-15(2)10-12-28-20-14-17(35-5)8-9-18(20)22-23(28)21(13-16(3)4)30-25(32)19-7-6-11-29(19)26(33)27(30,34)24(22)31/h8-10,13-14,19,21,24,31,34H,6-7,11-12H2,1-5H3/t19-,21-,24-,27+/m0/s1
12626-17-4Relevant articles and documents
FtmOx1, a non-heme Fe(ii) and α-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus
Steffan, Nicola,Grundmann, Alexander,Afiyatullov, Shamil,Ruan, Hanli,Li, Shu-Ming
supporting information; experimental part, p. 4082 - 4087 (2009/12/06)
Verruculogen is a tremorgenic mycotoxin and contains an endoperoxide bond. In this study, we describe the cloning, overexpression and purification of a non-heme Fe(ii) and α-ketoglutarate-dependent dioxygenase FtmOx1 from Aspergillus fumigatus, which cata
TOTAL SYNTHESIS OF FUMITREMORGIN B1
Nakatsuka, Shin-ihci,Teranishi, Katsunori,Goto, Toshio
, p. 6361 - 6364 (2007/10/02)
Total synthesis of fumitremorgin B, one of the potent tremorgic mycotoxins, was achieved in 7 steps.