1262786-40-2

Upstream product

• 5292-53-5 diethyl benzalmalonate 
• 41175-39-7 4-hydroxy-2-phenyl-butanenitrile 
• 29940-88-3 4-oxo-2-phenyl-butyronitrile 
• 14025-83-3 3-cyano-3-phenylpropanoic acid ethyl ester 
• 1262786-65-1 4-{3-[2-methyl-5-(1-methylethyl)-1H-imidazol-1-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenyl-1-butanamine 
• 98-09-9 benzenesulfonyl chloride 
• 1262786-64-0 4-{3-[2-methyl-5-(1-methylethyl)-1H-imidazol-1-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenyl-1-butanenitrile 

Relevant academic research and scientific papers

Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1

We describe the synthesis and potency of a novel series of N-substituted 2-phenyl- and 2-methyl-2-phenyl-1,4-diaminobutane- based CCR5 antagonists. Compounds 7a and 12f were found to be potent in anti-HIV assays and bioavailable in the low-dose rat PK model.

THERAPEUTIC COMPOUNDS

The present invention relates to compounds of Formula (I) and (Ia) useful in the treatment of CCR5-related diseases and disorders, for example, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficien