1262801-00-2Relevant academic research and scientific papers
Copper-Catalyzed (Di)Arylmethylation of Phosphorylamides Under Oxidative Conditions
Zhao, Zijian,Liu, Xiaobo,Hou, Anguo,Lian, Yan
, p. 6857 - 6866 (2019/01/04)
A compatible and practical (di)arylmethylation of phosphorylamides was successfully accessed in the presence of copper iodide as the catalyst, azodiisobutyronitrile as the radical initiator, and di-tert-butyl peroxide as the oxidant. Both methylarenes and diaryl methanes were compatible under the oxidative conditions, enjoying broad functional groups tolerance (51 examples) and good efficiency (up to 90 % yields).
Cobalt-catalyzed oxidative arylmethylation of phosphorylamides
Xiao, Jing,Li, Ping,Zhang, Yingjun,Xie, Dexun,Peng, Zhihong,An, Delie,Dong, Wanrong
, p. 4558 - 4568 (2018/07/30)
A cobalt-catalyzed strategy for N-arylmethylation of phosphorylamides was herein achieved with the assistance of azodiisobutyronitrile as the radical initiator and di-tert-butyl peroxide as the oxidant. Both methylarenes and diaryl methanes were compatible under the oxidative conditions, expressing broad substrate scope (51 examples) and high efficiency (up to 87% yield).
Staudinger-phosphonite reactions for the chemoselective transformation of azido-containing peptides and proteins
Vallee, M. Robert J.,Majkut, Paul,Wilkening, Ina,Weise, Christoph,Mueller, Gregor,Hackenberger, Christian P. R.
supporting information; experimental part, p. 5440 - 5443 (2011/12/04)
Site-specific functionalization of proteins by bioorthogonal modification offers a convenient pathway to create, modify, and study biologically active biopolymers. In this paper the Staudinger reaction of aryl-phosphonites for the chemoselective functiona
Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters
Wilkening, Ina,Signore, Giuseppe Del,Hackenberger, Christian P. R.
, p. 349 - 351 (2011/03/17)
The Staudinger reaction of unprotected azido-peptides with silylated phosphinic acids and esters on the solid support offers a straightforward acid-free entry to different phosphonamidate peptide esters or acids under mild conditions in high purity and yield.
