1262861-49-3

Upstream product

• 64373-43-9 5-methyl-3-oxo-hexanenitrile 
• 556-24-1 methyl 3-methylbutanoate 
• 851577-69-0 [5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]acetic acid 
• 851577-50-9 tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate 
• 851577-49-6 tert-butyl {[5-(hydroxymethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate 
• 851653-53-7 C₂₀H₂₆N₂O₂ 
• 851579-82-3 [5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate 
• 851577-38-3 methyl 5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carboxylate 
• 851577-40-7 methyl 5-cyano-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carboxylate 
• 851577-39-4 methyl 5-cyano-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)-1,4-dihydropyridine-3-carboxylate 
• 907611-08-9 5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile 
• 851586-54-4 methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate 

Relevant academic research and scientific papers

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

We have previously discovered nicotinic acid derivative 1 as a structurally novel dipeptidyl peptidase IV (DPP-4) inhibitor. In this study, we obtained the X-ray co-crystal structure between nicotinic acid derivative 1 and DPP-4. From these X-ray co-cryst