851577-40-7

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 5-cyano-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)-, methyl ester
• CAS NO: 851577-40-7
• Molecular Formula: C20H22N2O2
• Molecular Weight: 322.407
• Mol File: 851577-40-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 5-cyano-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 5-cyano-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)-, methyl ester(851577-40-7)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 5-cyano-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)-, methyl ester(851577-40-7)

Safety Data

• Hazardous Substances Data: 851577-40-7(Hazardous Substances Data)

Upstream product

• 64373-43-9 5-methyl-3-oxo-hexanenitrile 
• 556-24-1 methyl 3-methylbutanoate 
• 907611-08-9 5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile 
• 851577-39-4 methyl 5-cyano-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)-1,4-dihydropyridine-3-carboxylate 

Downstream Products

• 851577-38-3 methyl 5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carboxylate 
• 851577-57-6 ethyl (2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoate 
• 851577-42-9 methyl 5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carboxylate 
• 851578-41-1 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-6-isobutyl-2-methyl-4-(4-methylphenyl)pyridin-3-yl]propionic acid 
• 851578-39-7 ethyl 3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]propanoate 
• 851577-59-8 (2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoic acid 
• 851577-56-5 tert-butyl {[5-formyl-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate 
• 851577-43-0 5-(((tert-butoxycarbonyl)amino)methyl)-6-isobutyl-2-methyl-4-(4-methylphenyl)nicotinic acid 
• 851584-53-7 methyl 3-({[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]acetyl}amino)benzoate 
• 1262861-54-0 tert-butyl {[5-{2-[(2R)-2-carbamoylpyrrolidin-1-yl]-2-oxoethyl}-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)-pyridin-3-yl]methyl}carbamate 
• 851577-69-0 [5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]acetic acid 
• 1262861-50-6 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]acetyl}-D-proline 
• 1262861-49-3 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]acetyl}-L-proline 
• 851577-50-9 tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate 

Relevant articles and documents

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

We have previously discovered nicotinic acid derivative 1 as a structurally novel dipeptidyl peptidase IV (DPP-4) inhibitor. In this study, we obtained the X-ray co-crystal structure between nicotinic acid derivative 1 and DPP-4. From these X-ray co-cryst

REMEDY FOR DIABETES

The present invention provides an agent for increasing the pancreatic insulin content useful for the treatment of diabetes and the like. In one embodiment, the present invention provides an agent for increasing the pancreatic insulin content, which contai

PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV

A compound represented by the formula wherein R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted hydroxy group; R3 is an optionally substituted aromatic group; R4 is an optionally substituted amino group; L is a divalent chain hydrocarbon group; Q is a bond or a divalent chain hydrocarbon group; and X is a hydrogen atom, a cyano group, a nitro group, an acyl group, a substituted hydroxy group, an optionally substituted thiol group, an optionally substituted amino group or an optionally substituted cyclic group; provided that when X is an ethoxycarbonyl group, then Q is a divalent chain hydrocarbon group. The compound has a peptidase inhibitory action, is useful as an agent for the prophylaxis or treatment of diabetes and the like, and is superior in efficacy, duration of action, specificity, lower toxicity and the like.