126334-26-7Relevant academic research and scientific papers
Cu/Mn bimetallic catalysis enables carbonylative Suzuki-Miyaura coupling with unactivated alkyl electrophiles
Pye, Dominic R.,Cheng, Li-Jie,Mankad, Neal P.
, p. 4750 - 4755 (2017/07/10)
A bimetallic system consisting of Cu-carbene and Mn-carbonyl co-catalysts was employed for carbonylative C-C coupling of arylboronic esters with alkyl halides, allowing for the convergent synthesis of ketones. The system operates under mild conditions and exhibits complementary reactivity to Pd catalysis. The method is compatible with a wide range of arylboronic ester nucleophiles and proceeds smoothly for both primary and secondary alkyl iodide electrophiles. Preliminary mechanistic experiments corroborate a hypothetical catalytic mechanism consisting of co-dependent cycles wherein the Cu-carbene co-catalyst engages in transmetallation to generate an organocopper nucleophile, while the Mn-carbonyl co-catalyst activates the alkyl halide electrophile by single-electron transfer and then undergoes reversible carbonylation to generate an acylmanganese electrophile. The two cycles then intersect with a heterobimetallic, product-releasing C-C coupling step.
Traceless chelation-controlled rhodium-catalyzed intermolecular alkene and alkyne hydroacylation
Hooper, Joel F.,Young, Rowan D.,Weller, Andrew S.,Willis, Michael C.
supporting information, p. 3125 - 3130 (2013/03/28)
A new functional-group tolerant, rhodium-catalyzed, sulfide-reduction process is combined with rhodium-catalyzed chelation-controlled hydroacylation reactions to give a traceless hydroacylation protocol. Aryl- and alkenyl aldehydes can be combined with both alkenes, alkynes and allenes to give traceless products in high yields. A preliminary mechanistic proposal is also presented. Traceless catalysis: The powerful combination of a chelation-controlled hydroacylation process and a new rhodium-catalyzed sulfide reduction gave the products of traceless hydroacylation. Aryl- and alkenyl aldehydes can be combined with alkenes, alkynes, and allenes to deliver traceless products in high yields (see scheme). Copyright
ALYKYLENE DERIVATIVE HAVING EDG RECEPTOR ANTAGONISM
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Page/Page column 93, (2010/02/12)
PROBLEM TO BE SOLVED: To provide novel compounds having EDG (endothelial differentiation gene) receptor antagonism which are useful as active components of drugs for preventing and/or treating inflammatory diseases or the like. SOLUTION: The compounds are represented by formula (I) (wherein R1 is hydrogen or an alkyl group; R2 is hydrogen present at any substitutable position on ring C or a substituent such as a hydroxy group, a carboxy group, and a nitro group; R3 is hydrogen present at any substitutable position on ring D or a substitutent such as a hydroxy group and an aralkyloxy group; X is an alkylamino group, an amino group or the like; Y is a carboxy group, a sulfo group or a phosphono group; Z is oxygen, sulfur or the like; a ring represented by A is a 5- or 6-membered saturated or unsaturated hydrocarbon ring; and a ring represented by B is a 4- or 7-membered saturated or unsaturated hydrocarbon ring containing one -C=C- as a partial structure shown in the above formula) and include their salts and their esters.
The Synthesis and Transition Temperatures of Some 4,4"-dialkyl- and 4,4"-Alkoxyalkyl-1,1':4',1"-terphenyls with 2,3- or 2',3'-difluoro Substituents and of their Biphenyl Analogues
Gray, George W.,Hird, Michael,Lacey, David,Toyne, Kenneth J.
, p. 2041 - 2054 (2007/10/02)
The tetrakis(triphenylphosphine)palladium(o)-catalysed coupling of arylboronyc acids with aryl halides is used to prepare several 4,4"-dialkyl- and 4,4"-alkoxyalkyl-1,1':4',1"-terphenyls with 2,3- or 2',3'-difluoro substituents and their related biphenyl systems.Lithiation ortho to a 1,2-difluoroaromatic unit provides the route to the 2,3-difluoroarylboronic acids.The 2,3-difluoro substituted terphenyls are low-melting liquid crystals with wide-range Sc phases and no underlying smectic phase; these compounds are excellent hosts for ferroelectric systems.The compounds with widest Sc ranges are those with the difluoro substituents in an end ring and the compounds with difluoro substituents in the central ring show more nematic character and so are useful for ECB devices.
