Cas 1263575-78-5,5-methyl-4-(2-methylbenzyl)-2-phenyl-3,4-dihydro-2H-pyrazol-3-one

1263575-78-5

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Basic information

Product Name: 5-methyl-4-(2-methylbenzyl)-2-phenyl-3,4-dihydro-2H-pyrazol-3-one
Synonyms: 5-methyl-4-(2-methylbenzyl)-2-phenyl-3,4-dihydro-2H-pyrazol-3-one
CAS NO:1263575-78-5
Molecular Formula:
Molecular Weight: 278.354
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 5-methyl-4-(2-methylbenzyl)-2-phenyl-3,4-dihydro-2H-pyrazol-3-one(CAS DataBase Reference)
NIST Chemistry Reference: 5-methyl-4-(2-methylbenzyl)-2-phenyl-3,4-dihydro-2H-pyrazol-3-one(1263575-78-5)
EPA Substance Registry System: 5-methyl-4-(2-methylbenzyl)-2-phenyl-3,4-dihydro-2H-pyrazol-3-one(1263575-78-5)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1263575-78-5(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1263575-78-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,3,5,7 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1263575-78:
(9*1)+(8*2)+(7*6)+(6*3)+(5*5)+(4*7)+(3*5)+(2*7)+(1*8)=175
175 % 10 = 5
So 1263575-78-5 is a valid CAS Registry Number.

1263575-78-5Upstream product

1263575-78-5Downstream Products

1263575-78-5Relevant academic research and scientific papers

Design, Synthesis, and Structure-Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase

Zhang, Jing,Yang, Yang,Qian, Xing-Kai,Song, Pei-Fang,Zhao, Yi-Shu,Guan, Xiao-Qing,Zou, Li-Wei,Bao, Xiaoze,Wang, Hong

supporting information, p. 1600 - 1604 (2021/03/03)

Pancreatic lipase (PL), a key target for the prevention and treatment of obesity, plays crucial roles in the hydrolysis and absorption of in dietary fat. In this study, a series of pyrazolones was synthesized, and their inhibitory effects against PL were

Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells

Qian, Xing-Kai,Zhang, Jing,Song, Pei-Fang,Zhao, Yi-Su,Ma, Hong-Ying,Jin, Qiang,Wang, Dan-Dan,Guan, Xiao-Qing,Li, Shi-Yang,Bao, XiaoZe,Zou, Li-Wei

, (2021/05/10)

Carboxylesterase 2 (CES2) is one of the most important Phase I drug metabolizing enzymes in the carboxylesterase family. It plays crucial roles in the bioavailability of oral ester prodrugs and the therapeutic effect of some anticancer drugs such as irino

Organocatalytic Amination of Pyrazolones with Azodicarboxylates: Scope and Limitations

Formánek, Bed?ich,?eferna, Vít,Meazza, Marta,Rios, Ramon,Patil, Mahendra,Vesely, Jan

supporting information, p. 2362 - 2366 (2021/03/16)

The organocatalytic amination of pyrazol-5-ones with azodicarboxylates (catalyzed by quinine) is reported. This asymmetric process furnishes enantiomerically enriched hydrazine adducts containing quaternary stereocenters in high yields (74–96 %) and enant

Tunable Aerobic Oxidative Hydroxylation/Dehydrogenative Homocoupling of Pyrazol-5-ones under Transition-Metal-Free Conditions

Sheng, Xuguang,Zhang, Jinlong,Yang, Huameng,Jiang, Gaoxi

supporting information, p. 2618 - 2621 (2017/05/24)

A practical and tunable transition-metal-free aerobic oxidation of pyrazol-5-ones preparing either 4-hydroxypyrazoles (via C-H hydroxylation) or bispyrazoles (via dehydrogenative homocoupling) is described. The K2CO3/dioxane reagent system predominately promoted hydroxylation to deliver the α-hydroxylated pyrazoles. In contrast, the formation of bispyrazoles was overwhelmingly preferred with CH3CN as the reaction medium without any additives.

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