126362-89-8

Upstream product

• 109-01-3 1-methyl-piperazine 
• 126362-87-6 7-Chloro-1-(4-nitrophenyl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid 
• 100-01-6 4-nitro-aniline 
• 139396-15-9 (Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-nitro-phenylamino)-acrylic acid ethyl ester 
• 350-46-9 4-Fluoronitrobenzene 
• 75073-15-3 ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate 
• 126362-85-4 Ethyl 7-Chloro-6-fluoro-1,4-dihydro-1-(4-nitrophenyl)-4-oxoquinoline-3-carboxylate 
• 86483-51-4 ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate 
• 631898-47-0 6,7-difluoro-1,4-dihydro-7-(4-methylpiperazin-1-yl)-1-(4-nitrophenyl)-4-oxoquinoline-3-carboxylic acid 

Downstream Products

• 102855-98-1 1-(4-aminophenyl)-6-fluoro-1,4-dihydro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and antimycobacterial evaluation of certain fluoroquinolone derivatives

A number of fluoroquinolone derivatives were synthesized and evaluated for antimycobacterial activity. Preliminary results are (1) for 1-aryl fluoroquinolones, 1-(4-nitrophenyl) derivatives were inactive while their 1-(2-fluoro-4-nitrophenyl) counterparts

Synthesis, and antimycobacterial and cytotoxic evaluation of certain fluoroquinolone derivatives

Certain 1-ethyl- and 1-aryl-6-fluoro-1,4-dihydroquinol-4-one derivatives were synthesized and evaluated for antimycobacterial and cytotoxic activities. Preliminary results indicated that, for 1-aryl-6-fluoroquinolones, both 7-(piperazin-1-yl)- and 7-(4-me

Synthesis and antibacterial activity of 1-(substituted pyrrolyl)-7- (substituted amino)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

Seventeen quinolone compounds characterized by having a fluorine atom at the 6-position, a substituted amino at the 7-position, and a substituted pyrrolyl at the 1-position were synthesized for the first time. The in vitro antibacterial activities of thes

SYNTHESIS OF SOME 1-ARYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS AND THEIR ANTIBACTERIAL ACTIVITY

1,4-Dihydro-4-oxoquinoline-3-carboxylic acids VIIIc and VIIId were prepared via their ethyl esters VIIIa and VIIIb, which were obtained by a direct arylation of ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (VIa).When treated with piperazine or N-methylpiperazine compound VIIId yields VIIIe or VIIIf, respectively.Reduction of VIIId, VIIIe, and VIIIf with ferrous sulfate yields VIIIg, VIIIh, and VIIIi respectively.Diazotization and introduction of fluorine into VIIIg using hydrogen fluoride-pyridine yields VIIIj.The compounds prepared were testedfor their antimicrobial activity in vitro.