139396-15-9

Upstream product

• 100-01-6 4-nitro-aniline 
• 86483-52-5 2,4-dichloro-alpha(elhoxymethlene)-5-fluoro-beta-oxo-benzene propanoic acid ethyl ester 
• 104600-41-1 3-(2,4-dichloro-5-fluorophenyl)-3-oxo-2-ethoxymethylenepropanoic acid ethyl ester 
• 86483-51-4 ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate 

Downstream Products

• 139396-27-3 6-Fluoro-7-(3-methyl-piperidin-1-yl)-1-(4-nitro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 139396-25-1 6-Fluoro-1-(4-nitro-phenyl)-4-oxo-7-pyrrolidin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid 
• 126362-89-8 6-fluoro-1,4-dihydro-7-(4-methylpiperazin-1-yl)-1-(4-nitrophenyl)-4-oxoquinoline-3-carboxylic acid 
• 126362-85-4 Ethyl 7-Chloro-6-fluoro-1,4-dihydro-1-(4-nitrophenyl)-4-oxoquinoline-3-carboxylate 
• 126362-88-7 1-(4-nitrophenyl)-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 126362-87-6 7-Chloro-1-(4-nitrophenyl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of 1-(substituted pyrrolyl)-7- (substituted amino)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

Seventeen quinolone compounds characterized by having a fluorine atom at the 6-position, a substituted amino at the 7-position, and a substituted pyrrolyl at the 1-position were synthesized for the first time. The in vitro antibacterial activities of thes

Syntheses and biological activities of new N1-aryl substituted quinolone antibacterials

A series of quinolones with a systematically varied substitution at the phenyl ring at N1 has been synthesized. Three lipophilicity descriptors (log K, log P, R(m)) and the pK(a) values have been determined as well as the microbiological activity: The MIC