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126409-24-3

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  • (2R-(2R',4S',5S'))-N-(5-(((1,1-DIMETHYLETHOXY)CARBONYL)AMINO)-4-HYDROXY-1-OXO-6-PHENYL-2-BENZYLHEXYL)- L-LEUCYL- L-PHENYLALANINAMIDECAS

    Cas No: 126409-24-3

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  • L-Phenylalaninamide,N-[(2R,4S,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-(9CI)

    Cas No: 126409-24-3

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126409-24-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 126409-24-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,4,0 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 126409-24:
(8*1)+(7*2)+(6*6)+(5*4)+(4*0)+(3*9)+(2*2)+(1*4)=113
113 % 10 = 3
So 126409-24-3 is a valid CAS Registry Number.

126409-24-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-[(2S,3S,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate

1.2 Other means of identification

Product number -
Other names Boc-CH2Ph-Leu-Phe-NH2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:126409-24-3 SDS

126409-24-3Relevant articles and documents

Allyltrichlorostannane additions to α-amino aldehydes: Application to the total synthesis of the aspartyl protease inhibitors L-682,679, L-684,414, L-685,434, and L-685,458

Dias, Luiz C.,Diaz, Gaspar,Ferreira, Andrea A.,Meira, Paulo R. R.,Ferreira, Edílson

, p. 603 - 622 (2007/10/03)

The hydroxyethylene dipeptide isosteres L-682,679, L-684,414, L-685,434, and L-685,458 were synthesized in a few steps by a sequence involving an allyltrichlorostannane coupling with an α-amino aldehyde, followed by hydroboration of the corresponding 1,2-

HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: An investigation into the role of the P1' side chain on structure-activity

Young,Payne,Thompson,Gaffin,Lyle,Britcher,Graham,Schultz,Deana,Darke,Zugay,Schleif,Quintero,Emini,Anderson,Huff

, p. 1702 - 1709 (2007/10/02)

A systematic investigation was undertaken to determine the role of the P1' sidechain in a series of hydroxyethylene isostere based inhibitors of HIV-1 protease. Substitution and homologation of the benzyl P1' side chain of the Phe-Phe isostere based pseudo peptides 1 (L-682,679) and 2 (L-685,434) with various heteroalkyl groups leads to a series of extremely potent inhibitors of the enzyme. Several examples of the most potent inhibitors were very effective in an ex vivo cell based viral spread assay using human H9 T- lymphocytes and the IIIb isolate of HIV-1. Compound 19 is 120 times more potent than 1 and 16 times more potent than 2 in inhibiting the spread of infection in this assay.

L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor [2]

Vacca,Guare,deSolms,Sanders,Giuliani,Young,Darke,Zugay,Sigal,Schleif,Quintero,Emini,Anderson,Huff

, p. 1225 - 1228 (2007/10/02)

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