126443-12-7

Basic information

• Product Name: (2E)-1-(4-bromophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
• Synonyms: (2E)-1-(4-Bromophenyl)-3-(4-methoxyphenyl)-2-propen-1-one; 2-propen-1-one, 1-(4-bromophenyl)-3-(4-methoxyphenyl)-, (2E)-; trans-4'-Bromo-4-methoxychalcone
• CAS NO: 126443-12-7
• Molecular Formula: C₁₆H₁₃BrO₂
• Molecular Weight: 317.1772
• Mol File: 126443-12-7.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 449.3°C at 760 mmHg
• Flash Point: 225.5°C
• Density: 1.378g/cm³
• Vapor Pressure: 2.89E-08mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: (2E)-1-(4-bromophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(4-bromophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one(126443-12-7)
• EPA Substance Registry System: (2E)-1-(4-bromophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one(126443-12-7)

Safety Data

• Hazardous Substances Data: 126443-12-7(Hazardous Substances Data)

Usage

General Description

The chemical (2E)-1-(4-bromophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one, also known as 4'-bromo-4-methoxychalcone, is a compound with the molecular formula C16H13BrO2. It is a chalcone derivative, which is a type of flavonoid compound found in plants. This chemical has been studied for its potential pharmaceutical properties, including anti-inflammatory, anticancer, and antimicrobial effects. It is also used in some organic synthesis and chemical research applications. The 4'-bromo-4-methoxychalcone compound is of interest for its potential therapeutic benefits and its role in the development of new drugs and treatments.

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 99-73-0 para-bromophenacyl bromide 
• 201230-82-2 carbon monoxide 
• 5467-74-3 4-Bromophenylboronic acid 
• 136618-41-2 E-2'-p-methoxystyryl iodide 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 144309-64-8 (4S,5R)-5-(4-Bromo-benzoyl)-4-(4-methoxy-phenyl)-1-p-tolyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester 
• 648903-46-2 1-(4-bromophenyl)-3-(4-methoxyphenyl)propan-1-one 
• 1447235-42-8 2-(4-bromophenyl)-4-(4-methoxyphenyl)-1-tosyl-1,4-dihydroquinoline 
• 677328-23-3 2-(4-bromophenyl)-4-(4-methoxyphenyl)quinoline 
• 1447235-12-2 (E)-N-((E)-1-(4-bromophenyl)-3-(4-methoxyphenyl)allylidene)-4-methylbenzenesulfonamide 
• 6338-81-4 (E)-1-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 259668-52-5 3-(4''-bromophenyl)-5-(4'-methoxyphenyl)-1-phenylpyrazole 
• 93809-15-5 3-<4-Brom-benzoyl>-2-<4-methoxy-phenyl>-propionsaeure-methylester 

Relevant articles and documents

Novel chalcones as probes for in vivo imaging of β-amyloid plaques in Alzheimer's brains

A novel series of chalcone derivatives for in vivo imaging β-amyloid plaques in the brain of Alzheimer's disease (AD) were synthesized and characterized. When in vitro binding studies using Aβ aggregates were carried out with chalcone derivatives, the bin

From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

A ligand-based approach involving systematic modifications of a trisubstituted pyrazoline scaffold derived from the COX2 inhibitor, celecoxib, was used to develop novel PDE5 inhibitors. Novel pyrazolines were identified with potent PDE5 inhibitory activit

Fluorine as a robust balancer for tuning the reactivity of topo-photoreactions of chalcones and the photomechanical effects of molecular crystals

Fluorine-free chalcones and chalcones bearing different numbers of fluorine atoms have been synthesized. It is found that fluorine can tune the reactivity of photo-induced [2 + 2] cycloaddition reactions in crystals. The higher the number of fluorine atom