126443-21-8

Basic information

• Product Name: (E)-4,4'-Dibromochalcone
• Synonyms: (E)-4,4'-Dibromochalcone
• CAS NO: 126443-21-8
• Molecular Formula: C₁₅H₁₀Br₂O
• Molecular Weight: 366.05
• Mol File: 126443-21-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 184-185 °C
• Boiling Point: 450.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.647±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (E)-4,4'-Dibromochalcone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4,4'-Dibromochalcone(126443-21-8)
• EPA Substance Registry System: (E)-4,4'-Dibromochalcone(126443-21-8)

Safety Data

• Hazardous Substances Data: 126443-21-8(Hazardous Substances Data)

Usage

General Description

"(E)-4,4'-Dibromochalcone" is a chemical compound with the molecular formula C15H10Br2O. It belongs to the class of chalcones, which are chemical compounds that are part of the larger group of flavonoids. (E)-4,4'-Dibromochalcone is characterized by the presence of two bromine atoms in the 4 and 4' positions of the chalcone backbone, giving it its name. (E)-4,4'-Dibromochalcone has been studied for its potential biological and pharmacological activities, including its antibacterial, antifungal, and anti-inflammatory properties. It has also been investigated for its potential as a lead compound in drug discovery and development. The compound's potential applications make it an interesting target for further research and exploration.

Upstream product

• 5471-96-5 (E)-1,3-bis(4-bromophenyl)prop-2-en-1-one 
• 1122-91-4 4-bromo-benzaldehyde 
• 99-73-0 para-bromophenacyl bromide 
• 1777-57-7 p-bromobenzoylmethylenetriphenylphosphorane 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 5471-96-5 4,4'-dibromo-cis-chalcone 
• 100965-18-2 (2RS,3SR)-2,3-dibromo-1,3-bis-(4-bromo-phenyl)-propan-1-one 
• 399507-79-0 2,4,6-tris(4-bromophenyl)pyrimidine 
• 100965-18-2 1,3-bis(4-bromophenyl)-2,3-dibromopropanone 
• 55368-74-6 3,5-bis(4-bromophenyl)isoxazole 
• 33170-68-2 1,3-bis-(4-bromo-phenyl)-propane-1,3-dione 
• 204589-03-7 4,6-bis(4-cyanophenyl)-2-methylpyrimidine 
• 23274-53-5 (E)-1,3-di([1,1'-biphenyl]-4-yl)prop-2-en-1-one 
• 898761-28-9 1,3-bis(4-bromophenyl)propan-1-one 
• 204589-02-6 4,6-bis(4-bromophenyl)-2-methylpyrimidine 
• 61595-99-1 3-(4-bromophenyl)-5-(4-bromophenyl)-1-phenyl-2-pyrazoline 
• 494764-44-2 3,5-Bis-(4-bromo-phenyl)-4,5-dihydro-1H-pyrazole 

Relevant articles and documents

Synthesis and antimicrobial evaluation of arylated 1,3,5-triphenyl pyrazoline derivatives using suzuki-miyaura reactions

The first palladium –catalyzed coupling reactions of 1,3,5-triphenyl pyrazoline are reported. The Suzuki-Miyaura reaction of 3-(4-bromophenyl)-1,5-diphenyl pyrazoline with one equivalent of arylboronic acids afforded 3-(biphenyl)-1,5-diphenyl pyrazoline in 53-78 % yield. While the Suzuki-Miyaura reactions of 3,5-bis(4-bromophenyl)-1-phenyl pyrazoline with two equivalent of arylboronic acids gave 3,5-bis(biphenyl)-1-phenyl pyrazoline in 55-80% yield. The characterization of the synthesized derivatives (5a-h) and (6a-h) were accomplished on the basis of NMR, FT-IR, and mass techniques. The newly pyrazoline derivatives have been investigated for their in vitro antibacterial activity against gram- negative and gram-positive bacteria. The di-coupling compounds (6a-h) exhibited promising antibacterial against all four bacterial strains compared to the mono-coupling compounds (5a-h) which displayed a slight activity. The compound 6d showed a potent activity significantly more active than Trimethoprim (100μg/ml).

Synthesis of symmetrical and unsymmetrical triarylpyrylium ions: Via an inverse electron demand Diels-Alder reaction

BF3·OEt2 mediated inverse electron demand Diels-Alder (IEDDA) reaction of chalcones with aryl acetylenes is reported for the synthesis of symmetrical and unsymmetrical 2,4,6-triarylpyrylium ions. The protocol provides an effective one-pot method for the utilization of readily available simple substrates under mild reaction conditions leading to a diverse array of pyrylium ions in moderately good yield.

Mild and efficient reductive deoxygenation of epoxides to olefins with tin(II) chloride/sodium iodide as a novel reagent

A highly efficient and green protocol is reported for the reductive deoxygenation of organic epoxides to olefins using tin(II) chloride/sodium iodide as a novel reagent. The reaction gives an excellent yield (85-96%) in ethanol under reflux within 2-10 minutes, without affecting other functional groups. The advantages of our method are the use of inexpensive reagents, the eco-friendly and green reaction conditions, and the short reaction times and high yields.