126495-72-5

Upstream product

• 24131-31-5 3,5-dibenzyloxybenzyl alcohol 
• 2732-96-9 3,5-dibenzyloxyphenylacetic acid 
• 58604-84-5 (3',5'-dibenzyloxy)phenylacetonitrile 
• 79762-35-9 methyl 2-(3,5-bis(benzyloxy)-2-formylphenyl)acetate 
• 6512-33-0 2-acetyl-3,5-dimethoxyphenylacetic acid methyl ester 
• 819812-55-0 methyl 2-acetyl-3,5-diallyloxyphenylacetate 
• 58605-10-0 methyl 3,5-bis(benzyloxy)benzoate 
• 916197-35-8 C₇H₈O₃ 
• 74590-73-1 1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene 
• 4724-10-1 methyl 2-(3,5-dihydroxyphenyl)acetate 
• 108-24-7 acetic anhydride 
• 65857-78-5 methyl 2-acetyl-3,5-bis(benzyloxy)phenylacetate 

Downstream Products

• 18512-30-6 1,3,6,8-Tetrahydroxynaphthalene 
• 49598-85-8 3,6,8-Trihydroxy-3,4-dihydronaphthalen-1(2H)-one 
• 77053-29-3 6,8-dihydroxy-1-methylisochroman-3-one 
• 1389342-19-1 C₁₇H₁₄O₇ 
• 1389342-17-9 C₁₇H₁₄O₇ 
• 1389342-53-3 C₂₉H₂₈O₁₁ 
• 1389342-32-8 C₁₈H₁₅ClO₆ 
• 1389341-60-9 C₂₃H₃₂O₇ 
• 1389342-26-0 C₁₉H₁₈O₇ 
• 1389342-23-7 C₁₈H₁₆O₇ 
• 1389342-27-1 C₁₈H₁₆O₆ 

Relevant academic research and scientific papers

A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis

Bacterial meroterpenoids constitute an important class of natural products with diverse biological properties and therapeutic potential. The biosynthetic logic for their production is unknown and defies explanation via classical biochemical paradigms. A l

HSP90 FAMILY PROTEIN INHIBITORS

The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I): (wherein n represents an integer of 0 to 10; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl or the like; and R4 and R6, which may be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like) or a prodrug thereof, or a pharmaceutically acceptable salt of said benzoyl compound or said prodrug.

A total synthesis of xestodecalactone A and proof of its absolute stereochemistry: Interesting observations on dienophilic control with 1,3-disubstituted nonequivalent allenes

A concise total synthesis of xestodecalactone A, utilizing a Diels-Alder strategy is described. The focal Diels-Alder reaction relied on an "ynoate" dienophile to rapidly assemble the required resorcylinic acid scaffold. During this study, Diels-Alder cycloaddition reactions involving 1,3-disubstituted nonequivalent allene dienophiles were studied, and some surprising results were encountered.

Mechanistic studies on the biomimetic reduction of tetrahydroxynaphthalene, a key intermediate in melanin biosynthesis

1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an aromatic polyketide, serving as a general precursor of fungal melanin. Melanin biosynthesis involves two consecutive deoxygenations of T4HN, consisting of the reduction of a phenolic carbon followed by dehydrat

DEOXYGENATION IN THE BIOSYNTHESIS OF POLYKETIDES: MECHANISM OF BIOMIMETIC REDUCTION OF TETRAHYDROXYNAPHTHALENE

A biomimetic synthesis of scytalone, a simple derivative of tetralone, was reinvestigeted using NMR spectroscopy.Scytalone was formed from 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by sodium borohydride reduction only in the presence of sodium methoxi