126587-59-5

Upstream product

• 126587-71-1 Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester 
• 118171-80-5 (2S)-3-[4-(methyloxy)phenyl]-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propanoic acid 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 185461-75-0 (2S,3R)-3-Benzyloxy-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester 
• 192211-84-0 (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 2592-18-9 Boc-Thr-OH 
• 1164-16-5 Z-L-Tyr-OH 

Downstream Products

• 126587-60-8 N,O-dimethyltyrosine-O-Boc-threonine-OSEM 
• 126587-62-0 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4- 
• 126587-64-2 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3S)-1-isopropyl-2- 
• 1053630-19-5 C₆₆H₁₀₇N₅O₁₆Si 
• 126587-63-1 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop 
• 148339-15-5 C₅₈H₁₀₁N₅O₁₅Si 
• 126587-61-9 Z-leucylprolyl-N,O-dimethyltyrosine-O-Boc-threonine-OSEM 
• 129919-84-2 Z-leucylprolyl-N,O-dimethyltyrosine-O-Boc-threonine 
• 185461-56-7 Boc-Thr[Z-N(Me)-O(Me)-Tyr]-Ist-Hip-Leu-Pro-OBzl 
• 185461-51-2 Boc-didemnin A 
• 185461-57-8 C₄₇H₇₅N₅O₁₄ 
• 137219-37-5 dehydrodidemnin B 
• 185461-52-3 C₄₇H₇₃N₅O₁₃ 
• 120286-04-6 (5S,8S,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-15-((S)-sec-butyl)-14-hydroxy-5-isobutyl-10-isopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone 

Relevant academic research and scientific papers

Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution

New total syntheses of didemnin A and of dehydrodidemnin B are described. The latter didemnin has the highest antiproliferative activity of all members of this family of macrocyclic depsipeptides. It was produced on coupling the side chain Pyr-Pro-OH to d

SYNTHETIC STUDIES OF DIDEMNINS. IV. SYNTHESIS OF THE MACROCYCLE

A stereocontrolled route to the 23-membered macrocycle found in the didemnins is described.