185461-76-1

Upstream product

• 126587-59-5 Z-N,O-dimethyltyrosine-O-Boc-threonine-OSEM 
• 1221232-06-9 Cbz-N,O-dimethyltyrosine-N-Boc-threonine-OMe 
• 185461-75-0 (2S,3R)-3-Benzyloxy-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester 
• 118171-80-5 (2S)-3-[4-(methyloxy)phenyl]-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propanoic acid 
• 126587-71-1 Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 

Downstream Products

• 766513-88-6 C₅₆H₇₉N₅O₁₅ 
• 1221232-00-3 C₅₈H₈₁N₅O₁₅ 
• 185461-51-2 Boc-didemnin A 
• 185461-57-8 C₄₇H₇₅N₅O₁₄ 
• 137219-37-5 dehydrodidemnin B 
• 185461-52-3 C₄₇H₇₃N₅O₁₃ 
• 120286-04-6 (5S,8S,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-15-((S)-sec-butyl)-14-hydroxy-5-isobutyl-10-isopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone 

Relevant academic research and scientific papers

An efficient synthesis of the tamandarin B macrocycle

A reliable, high yielding cyclization protocol for the macrocycle of tamandarin B is presented. This strategy will facilitate the synthesis of side chain analogs.

Total synthesis of dehydrodidemnin B. Use of uronium and phosphonium salt coupling reagents in peptide synthesis in solution

New total syntheses of didemnin A and of dehydrodidemnin B are described. The latter didemnin has the highest antiproliferative activity of all members of this family of macrocyclic depsipeptides. It was produced on coupling the side chain Pyr-Pro-OH to d