1266226-62-3

Basic information

• Product Name: C₃₂H₃₂Br₂N₂O₄Pd₂
• CAS NO: 1266226-62-3
• Molecular Weight: 881.265
• Mol File: 1266226-62-3.mol

Chemical Properties

• CAS DataBase Reference: C₃₂H₃₂Br₂N₂O₄Pd₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₂H₃₂Br₂N₂O₄Pd₂(1266226-62-3)
• EPA Substance Registry System: C₃₂H₃₂Br₂N₂O₄Pd₂(1266226-62-3)

Safety Data

• Hazardous Substances Data: 1266226-62-3(Hazardous Substances Data)

Upstream product

• 75984-69-9 methyl N-p-chlorobenzylidene(phenyl)glycinate 
• 1417598-22-1 C₂₃H₂₀ClNO₂ 
• 3375-31-3 palladium diacetate 
• 118783-29-2 methyl 2-amino-2,3-diphenylpropanoate 
• 7550-35-8 lithium bromide 
• 100-39-0 benzyl bromide 

Relevant articles and documents

NH2 as a directing group: From the cyclopalladation of amino esters to the preparation of benzolactams by palladium(II)-catalyzed carbonylation of N-unprotected arylethylamines

An unusual NH2-directed Pd(II)-catalyzed carbonylation of quaternary aromatic α-amino esters to yield benzolactams has been developed. The steric hindrance around the amino group is pivotal for the success of the process. The stoichiometric cyclometalation of a variety amino esters has been studied in order to evaluate the influence of the different variables (size of the metallacycle, aromatic ring substituents, and steric bulk) in the process, and a complete kinetico-mechanistic study of the cyclopalladation process has been carried out. The experimental results indicate that the full substitution of the carbon in the α position of the amino esters plays an important role in their cyclopalladation reaction. The reaction shows a strong bias toward six-membered lactams over the five-membered analogues, which can be explained by a greater reactivity of the six-membered palladacycles.