126712-05-8Relevant articles and documents
Total synthesis of (S)-equol
Heemstra, Jennifer M.,Kerrigan, Sean A.,Doerge, Daniel R.,Helferich, William G.,Boulanger, William A.
, p. 5441 - 5443 (2006)
The first enantioselective total synthesis of (S)-equol is reported. The described route relies on an Evans alkylation to form the stereocenter and an intramolecular Buchwald etherification to generate the chroman ring. Key features of this method include its brevity, its scalability, and the low cost of starting materials.
SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF
-
Paragraph 0227, (2020/10/20)
Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.
Divergent Enantioselective Synthesis of (Nor)illudalane Sesquiterpenes via Pd0-Catalyzed Asymmetric C(sp3)-H Activation
Melot, Romain,Craveiro, Marcus V.,Bürgi, Thomas,Baudoin, Olivier
, p. 812 - 815 (2019/01/21)
A divergent enantioselective synthesis of (nor)illudalane sesquiterpenes was designed by using a Pd0-catalyzed asymmetric C(sp3)-H arylation as a key step to control the isolated, highly symmetric quaternary stereocenter of the targe
