124639-28-7

Basic information

• Product Name: 2-(2-methoxyphenyl)-1,3-dimethylimidazolidine
• Synonyms: 2-(2-methoxyphenyl)-1,3-dimethylimidazolidine
• CAS NO: 124639-28-7
• Molecular Weight: 206.288
• Mol File: 124639-28-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(2-methoxyphenyl)-1,3-dimethylimidazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methoxyphenyl)-1,3-dimethylimidazolidine(124639-28-7)
• EPA Substance Registry System: 2-(2-methoxyphenyl)-1,3-dimethylimidazolidine(124639-28-7)

Safety Data

• Hazardous Substances Data: 124639-28-7(Hazardous Substances Data)

Usage

Chemical family

Imidazolidine

Structural components

Methoxyphenyl group
Two methyl groups

Usage

Reagent in organic synthesis and pharmaceutical research

Value

Unique structure and properties for drug development and complex organic molecule production

Stability

High

Toxicity

Low

Desirability

Suitable for various chemical processes and applications due to stability and low toxicity

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 110-70-3 N,N`-dimethylethylenediamine 

Downstream Products

• 67853-41-2 2-methoxy-6-methylthiobenzaldehyde 
• 67868-80-8 2-methoxy-3-methylthiobenzaldehyde 
• 5025-59-2 2-iodo-6-methoxybenzaldehyde 
• 1242319-88-5 C₂₇H₂₃BrO₃ 
• 1242319-64-7 C₁₂H₁₈BrO₄P 
• 93710-52-2 (2-bromo-6-methoxyphenyl)methanol 
• 126712-05-8 1-bromo-2-(bromomethyl)-3-methoxybenzene 
• 206002-16-6 (E)-3-[(2-(benzyloxy)-6-bromophenyl)methylene]-2,3-dihydro-5,6-dimethoxy-2-[(4-methoxyphenyl)methyl]-1H-isoindol-1-one 
• 206002-17-7 2-(benzyloxy)-6-bromobenzaldehyde 
• 126712-07-0 2-bromo-6-methoxybenzaldehyde 
• 22532-61-2 2-bromo-6-hydroxybenzaldehyde 

Relevant articles and documents

INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE - SYNTHESIS AND USE THEREOF FOR TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AND LYMPHOMA

The present invention relates to new compounds of general formula I, their synthesis, their pharmaceutically acceptable salts, and their use in treatment of T-cell acute lymphoblastic leukemia and lymphoma.

The unexpected role of pyridine-2-carboxylic acid in manganese based oxidation catalysis with pyridin-2-yl based ligands

A number of manganese-based catalysts employing ligands whose structures incorporate pyridyl groups have been reported previously to achieve both high turnover numbers and selectivity in the oxidation of alkenes and alcohols, using H2O2 as terminal oxidant. Here we report our recent finding that these ligands decompose in situ to pyridine-2-carboxylic acid and its derivatives, in the presence of a manganese source, H2O 2 and a base. Importantly, the decomposition occurs prior to the onset of catalysed oxidation of organic substrates. It is found that the pyridine-2-carboxylic acid formed, together with a manganese source, provides for the observed catalytic activity. The degradation of this series of pyridyl ligands to pyridine-2-carboxylic acid under reaction conditions is demonstrated by 1H NMR spectroscopy. In all cases the activity and selectivity of the manganese/pyridyl containing ligand systems are identical to that observed with the corresponding number of equivalents of pyridine-2-carboxylic acid; except that, when pyridine-2-carboxylic acid is used directly, a lag phase is not observed and the efficiency in terms of the number of equivalents of H 2O2 required decreases from 6-8 equiv. with the pyridin-2-yl based ligands to 1-1.5 equiv. with pyridine-2-carboxylic acid.

Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors

The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.