1267498-35-0Relevant articles and documents
Mitsunobu inversion of a secondary alcohol with diphenylphosphoryl azide. application to the enantioselective multikilogram synthesis of a HCV polymerase inhibitor
Scott, Jeremy P.,Alam, Mahbub,Bremeyer, Nadine,Goodyear, Adrian,Wilson, Robert D.,Lam, Thientu,Zhou, George
, p. 1116 - 1123 (2012/01/03)
The development of a practical synthesis of the hepatitis C virus polymerase inhibitor 1 was necessary to support preclinical safety and human clinical studies. Significant challenges face the process chemist in developing a route to 1 that is amenable to