126813-46-5Relevant academic research and scientific papers
Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy
Devisscher, Lars,Van Coillie, Samya,Hofmans, Sam,Van Rompaey, Dries,Goossens, Kenneth,Meul, Eline,Maes, Louis,De Winter, Hans,Van Der Veken, Pieter,Vandenabeele, Peter,Berghe, Tom Vanden,Augustyns, Koen
, p. 10126 - 10140 (2018)
Ferroptosis is an iron-catalyzed, nonapoptotic form of regulated necrosis that results in oxidative lipid damage in cell membranes that can be inhibited by the radical-trapping antioxidant Ferrostatin-1 (Fer-1). Novel inhibitors derived from the Fer-1 sca
3-(BENZYLAMINO)-4-(CYCLOHEXYLAMINO)-N-(2-(PIPERAZIN-1-YL)ETHYL)BENZENESULFONAMIDE DERIVATIVES AND RELATED FERROSTATIN-1 ANALOGUES AS CELL DEATH INHIBITORS FOR TREATING E.G. STROKE
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Page/Page column 24; 26, (2019/08/29)
The present invention relates to 3-(benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 (Fer-1) analogues as cell death inhibitors by inhibition of ferroptosis and/or oxytosis for the treatm
Synthesis and evaluation of some nitrobenzenesulfonamides containing nitroisopropyl and (ureidooxy)methyl groups as novel hypoxic cell selective cytotoxic agents
Saari,Schwering,Lyle,Engelhardt,Sartorelli,Rockwell
, p. 3132 - 3138 (2007/10/02)
Basic nitrobenzenesulfonamides containing nitroisopropyl and (ureidooxy)methyl groups were prepared and evaluated as novel hypoxic cell selective cytotoxic agents. In vitro, N-(2-aminoethyl)-N-methyl-3-nitro-4-(1-methyl-1-nitroethyl) benzenesulfonamide hy
