Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

DOI: 10.1021/acs.jmedchem.8b01299

Source and publish data:

Journal of Medicinal Chemistry p. 10126 - 10140 (2018)

Update date:2022-08-15

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Authors:

Devisscher, Lars

Van Coillie, Samya

Hofmans, Sam

Van Rompaey, Dries

Goossens, Kenneth

Meul, Eline

Maes, Louis

De Winter, Hans

Van Der Veken, Pieter

Vandenabeele, Peter

Berghe, Tom Vanden

Augustyns, Koen

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Article abstract of DOI:10.1021/acs.jmedchem.8b01299

Ferroptosis is an iron-catalyzed, nonapoptotic form of regulated necrosis that results in oxidative lipid damage in cell membranes that can be inhibited by the radical-trapping antioxidant Ferrostatin-1 (Fer-1). Novel inhibitors derived from the Fer-1 sca

Full text of DOI:10.1021/acs.jmedchem.8b01299

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