1268249-86-0Relevant academic research and scientific papers
Organocatalyzed regioselective and enantioselective synthesis of 1,4- and 1,2-dihydropyridines
Le, Truong-Giang,Pham, Hoai-Thu,Martin, James P.,Chataigner, Isabelle,Renaud, Jean-Luc
supporting information, p. 2673 - 2684 (2020/08/07)
Herein, we introduce one of the first examples of asymmetric organocatalyzed synthesis of 1,2-dihydropyridines, affording enantioselective access to and partially solving regioselectivity challenges in the synthesis of dihydropyridines. We demonstrate that through modification of organocatalysts both 1,2- and 1,4-dihydropyridines (1,2- and 1,4-DHPs) can be obtained with high regioselectivity (ratio of 1,2-DHP/1,4-DHP from 95/5 to 0/100) and enantioselectivity (33% ee for 1,2-DHPs and up to 98% ee for 1,4-DHPs) in good yields (up to 87%).
Rhodium-catalyzed enantioselective addition of boronic acids to N -benzylnicotinate salts
Christian, Nadeau,Aly, Sara,Belyk, Kevin
, p. 2878 - 2880 (2011/05/12)
The highly enantioselective catalytic asymmetric addition of aryl and alkenylboronic acids to N-benzylnicotinate salt 1 is described. The dihydropyridine 2 reaction products can be converted to synthetically useful piperidines. Application of the methodol
