1268461-16-0

Upstream product

• 38556-93-3 4-azido-benzoic acid ethyl ester 
• 536-74-3 phenylacetylene 
• 99-77-4 ethyl 4-nitrobenzoate 
• 94-09-7 p-aminoethylbenzoate 
• 122-78-1 phenylacetaldehyde 
• 150-13-0 4-amino-benzoic acid 
• 532-27-4 1-chloroacetophenone 
• 71094-28-5 N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide 
• 4545-21-5 acetophenone p-toluenesulfonylhydrazone 
• 1680-44-0 4-phenyl-1H-1,2,3-triazole 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 4334-88-7 p-ethoxycarbonylphenylboronic acid 

Relevant academic research and scientific papers

Copper(I)-Chelated Cross-Linked Cyclen Micelles as a Nanocatalyst for Azide-Alkyne Cycloaddition in Both Water and Cells

Featuring the dendrimer-like properties, the cross-linked small-molecule micelles (cSMs) have been shown to be a good alternative to dendrimers in many applications. Following this trend, herein the copper(I)-chelated cross-linked cyclen micelles (Cu

Mechanism study of copper-mediated one-pot reductive amination of aryl halides using trimethylsilyl azide

Reaction mechanisms of the copper-mediated amination of aryl halides with trimethylsilyl azide (TMSN3) were analyzed on the basis of the time-course study using reaction monitoring FT-IR, trapping an intermediary aryl azide by the Huisgen reaction, and the analysis of the generated N2 gas during the reaction. This amination would proceed through multiple pathways via aryl radicals and copper(I) azide.

Iodine-mediated C-N and N-N bond formation: A facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions

A novel strategy towards the synthesis of 1,4-disubstituted 1,2,3-triazoles via C-N and N-N bond formation has been demonstrated under transition metal-free and azide-free conditions. These 1,2,3-triazoles were obtained in a regioselective manner from commercially available anilines, aryl alkenes/aryl alkynes and N-tosylhydrazines using I2 under O2 atmosphere. Broad substrate scope, milder reaction conditions, good to moderate yields and clean protocol are the notable features of the method. Moreover, this protocol is amenable for the generation of a library of medicinally important key building blocks.

Smectic liquid crystals comprising triazole banana shaped achiral molecules: Synthesis and characterization

A series of novel liquid crystals containing [1,2,3]-triazole ring were synthesized via “click chemistry.” Their mesomorphic properties and photoelectric properties were investigated and the results indicated that most of compounds exhibited SmA over a wide temperature range (about 50°C). The threshold voltage and the response time of the mixture, T4 and LC 50100 were shorten 0.43?V and 71.5?ms with respect to those of LC 50100 respectively.

One-pot synthesis of 1,4-disubstituted 1,2,3-triazoles from nitrobenzenes

A facile synthesis of 1,4-disubstituted 1,2,3-triazoles was achieved from nitrobenzenes and terminal alkynes under mild conditions. The reactions were successful for nitrobenzenes and terminal alkynes bearing various functionalities, from which the 1,2,3-triazole derivatives were smoothly synthesized through a four-step one-pot sequence.

An Efficient Copper-Catalyzed One-Pot Synthesis of 1-Aryl-1,2,3-triazoles from Arylboronic Acids in Water under Mild Conditions

A convenient method for one-pot two-step 1,3-dipolar cycloadditon reaction of arylboronic acid, sodium azide followed with terminal alkynes in the presence of 2-pyrrolecarbaldiminato-Cu(II) complexes catalyst is reported. Various 1-aryl-1,2,3-triazoles were prepared in 63%-97% yields in water at 30C without any additives and avoiding the isolation of unstable aryl azides.

Oximinoalkylamines as ligands for Cu-assisted azide-acetylene cycloaddition

Oximinoalkylamines were found to be efficient ligands for acceleration of the CuAAC reaction. 'Mixed' oxime-triazole ligands TzβOx2 and Tz2βOx demonstrate an approximately 10-fold enhanced acceleration effect co

Aerobic Oxidative Cycloaddition of α-Chlorotosylhydrazones with Arylamines: General Chemoselective Construction of 1,4-Disubstituted and 1,5-Disubstituted 1,2,3-Triazoles under Metal-Free and Azide-Free Conditions

A novel synthetic approach toward 1,4-disubstituted 1,2,3-triazoles and 1,5-disubstituted 1,2,3-triazoles by aerobic oxidative cycloaddition of α-chlorotosylhydrazone with primary aryl amine has been developed. Significantly, the reaction proceeds smoothl

I2/TBPB mediated oxidative reaction of N-tosylhydrazones with anilines: Practical construction of 1,4-disubstituted 1,2,3-triazoles under metal-free and azide-free conditions

An efficient I2 (20 mol %)/TBPB mediated oxidative formal [4 + 1] cycloaddition of N-tosylhydrazones with anilines via C-N/N-N bond formation and S-N cleavage has been developed. This protocol represents a simple, general, and efficient approac

An organocatalytic azide-aldehyde [3+2] cycloaddition: High-yielding regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles

An organocatalytic azide-aldehyde [3+2] cycloaddition (organo-click) reaction of a variety of enolizable aldehydes is reported. The organo-click reaction is characterized by a high rate and regioselectivity, mild reaction conditions, easily available subs