1268511-99-4

Usage

Uses

Used in Organic Synthesis:
Trans-3-amino-1-Boc-4-hydroxypiperidine is used as a building block for the synthesis of various pharmaceutical compounds and bioactive molecules. Its unique structural properties, including the trans configuration and functional groups, make it a valuable component in the development of new organic compounds.
Used in Medicinal Chemistry:
Trans-3-amino-1-Boc-4-hydroxypiperidine is used as a key intermediate in the synthesis of pharmaceutical compounds. Its versatility and ability to be modified through organic synthesis make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Pharmaceutical Industry:
Trans-3-amino-1-Boc-4-hydroxypiperidine is used as a starting material for the production of various pharmaceutical compounds. Its unique structure and functional groups allow for the creation of innovative and effective medications, contributing to advancements in healthcare and medicine.

Upstream product

• 161157-50-2 tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate 
• 725715-12-8 3-(phenylmethyl)-7-oxa-3-azabicyclo[4.1.0]heptane 
• 40240-12-8 1-benzyl-1,2,3,6-tetrahydropyridine 
• 110-86-1 pyridine 
• 2589-31-3 N-benzylpyridinium bromide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1510866-72-4 (3S,4S)-3-aminopiperidin-4-ol 
• 1161931-95-8 (3R,4R)-4-benzylamino-3-hydroxy-4-piperidine-1-carboxylic acid tert-butyl ester 
• 85838-94-4 N-Boc-1,2,3,6-tetrahydropyridine 

Downstream Products

• 1283718-72-8 tert-butyl 3-amino-4,4-difluoropiperidine-1-carboxylate 
• 1283718-72-8 tert-butyl 3-amino-4,4-difluoropiperidine-1-carboxylate 
• 1363286-66-1 4-oxo-3-[(phenoxyacetyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester 
• 1363286-69-4 6,7-dihydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine-5(4H)-carboxylic acid 1,1-dimethylethyl ester 
• 1363286-71-8 4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[4,5-c]pyridine 
• 1510832-31-1 (3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate 
• 1510832-33-3 (3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride 
• 1510832-36-6 C₂₁H₂₃ClF₄N₆O₂ 
• 1510832-80-0 C₂₆H₃₇ClF₃N₃O₆ 
• 1510832-82-2 C₁₇H₂₁ClF₃N₃O₂ 
• 1510832-47-9 C₂₄H₃₅ClF₃N₃O₅ 

Relevant academic research and scientific papers

Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists

A series of cis-3,4-disubstituted piperidines was synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. Compound 24 emerged with an attractive profile, possessing excellent binding (CCR2 IC50 = 3.4 nM) and functional antagonism (calcium flux IC50 = 2.0 nM and chemotaxis IC50 = 5.4 nM). Studies to explore the binding of these piperidine analogs utilized a key CCR2 receptor mutant (E291A) with compound 14 and revealed a significant reliance on Glu291 for binding.

INHIBITORS OF BRUTON'S TYROSINE KINASE

The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.

BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS

In one aspect, the invention relates to novel bicyclic oxazole and thiazole compounds which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5"); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions; and methods for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

METHYLPYRROLOPYRIMIDINECARBOXAMIDES

The compounds of Formula (I), wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.

METHYLPYRROLOPYRIMIDINECARBOXAMIDES

The compounds of formula (I) wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, and the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiestera

METHYLPYRROLOPYRIDINECARBOXAMIDES

The compounds of formula (I) wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, and the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.

DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT

The present invention relates to novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV(DPP-IV), methods of preparing the same and pharmaceutical compositions containing the same as an active agent.

Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole

A series of β-aminoacylpiperidines bearing various fused five-membered heterocyclic rings was synthesized as dipeptidyl peptidase IV inhibitors. Potent and relatively selective inhibition could be obtained, depending on choice of heterocycle, regioisomerism, and substitution. In particular, one analog (74, DPP-IV IC50 = 26 nM) exhibited good oral bioavailability and acceptable half-life in the rat, albeit with rather high clearance.

CHEMICAL COMPOUNDS

The use of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein X1, X2, X3, X4, Ra, p, R1,Z,Y, R2, R3 and R4 are as d