1268511-99-4 Usage
Description
Trans-3-amino-1-Boc-4-hydroxypiperidine is a chemical compound that belongs to the class of piperidines. It is an amino acid derivative that contains an amino group (-NH2) and a hydroxyl group (-OH) attached to a piperidine ring. The Boc (tert-butoxycarbonyl) group is a protecting group that is commonly used in organic synthesis to protect amines and prevent unwanted reactions. Trans-3-amino-1-Boc-4-hydroxypiperidine has potential applications in organic synthesis and medicinal chemistry due to its unique structural properties. Its trans configuration and functional groups make it a useful building block for the synthesis of various pharmaceutical compounds and bioactive molecules.
Uses
Used in Organic Synthesis:
Trans-3-amino-1-Boc-4-hydroxypiperidine is used as a building block for the synthesis of various pharmaceutical compounds and bioactive molecules. Its unique structural properties, including the trans configuration and functional groups, make it a valuable component in the development of new organic compounds.
Used in Medicinal Chemistry:
Trans-3-amino-1-Boc-4-hydroxypiperidine is used as a key intermediate in the synthesis of pharmaceutical compounds. Its versatility and ability to be modified through organic synthesis make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Pharmaceutical Industry:
Trans-3-amino-1-Boc-4-hydroxypiperidine is used as a starting material for the production of various pharmaceutical compounds. Its unique structure and functional groups allow for the creation of innovative and effective medications, contributing to advancements in healthcare and medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 1268511-99-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,8,5,1 and 1 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1268511-99:
(9*1)+(8*2)+(7*6)+(6*8)+(5*5)+(4*1)+(3*1)+(2*9)+(1*9)=174
174 % 10 = 4
So 1268511-99-4 is a valid CAS Registry Number.
1268511-99-4Relevant articles and documents
Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists
Cherney, Robert J.,Nelson, David J.,Lo, Yvonne C.,Yang, Gengjie,Scherle, Peggy A.,Jezak, Heather,Solomon, Kimberly A.,Carter, Percy H.,Decicco, Carl P.
, p. 5063 - 5065 (2008)
A series of cis-3,4-disubstituted piperidines was synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. Compound 24 emerged with an attractive profile, possessing excellent binding (CCR2 IC50 = 3.4 nM) and functional antagonism (calcium flux IC50 = 2.0 nM and chemotaxis IC50 = 5.4 nM). Studies to explore the binding of these piperidine analogs utilized a key CCR2 receptor mutant (E291A) with compound 14 and revealed a significant reliance on Glu291 for binding.
BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
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Page/Page column 132, (2012/03/26)
In one aspect, the invention relates to novel bicyclic oxazole and thiazole compounds which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5"); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions; and methods for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
METHYLPYRROLOPYRIMIDINECARBOXAMIDES
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Page/Page column 176, (2011/04/14)
The compounds of formula (I) wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, and the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiestera