126866-16-8

Basic information

• Product Name: 2-(4-Chlorophenyl)-1-(4-fluorophenyl)ethanone
• Synonyms: 2-(4-Chlorophenyl)-1-(4-fluorophenyl)ethanone
• CAS NO: 126866-16-8
• Molecular Formula: C₁₄H₁₀ClFO
• Molecular Weight: 248.6800032
• Mol File: 126866-16-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-Chlorophenyl)-1-(4-fluorophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-1-(4-fluorophenyl)ethanone(126866-16-8)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-1-(4-fluorophenyl)ethanone(126866-16-8)

Safety Data

• Hazardous Substances Data: 126866-16-8(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)-1-(4-fluorophenyl)ethanone is a chemical compound with the molecular formula C14H10ClF. It is also known as 4'-chloro-α,α,α-trifluoro-p-tolualdehyde and is used in the synthesis of pharmaceuticals and organic compounds. It is a yellowish liquid with a strong, sweet odor and is primarily used as an intermediate in the production of various drugs and agrochemicals. The compound may also be used in the synthesis of various other chemicals and can be found in research and development laboratories for its potential medicinal and therapeutic properties. Additionally, it is important to handle this chemical with care as it may pose health hazards if not used properly.

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 462-06-6 fluorobenzene 
• 25026-34-0 4-chlorophenacetyl chloride 
• 38695-17-9 1-(4-chlorophenyl)-1-(4-fluorophenyl)ethene 

Downstream Products

• 157383-94-3 1-(4-chlorophenyl)-2-(4-fluorophenyl)-1,2-ethanedione 
• 107680-08-0 (2R,3R)-2-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-1-[1,2,4]triazol-1-yl-pentane-2,3-diol 
• 107680-07-9 (2R,3S)-2-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-1-[1,2,4]triazol-1-yl-pentane-2,3-diol 
• 107679-99-2 (2R,3S)-2-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-1-[1,2,4]triazol-1-yl-butane-2,3-diol 
• 107680-00-2 (2R,3R)-2-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-1-[1,2,4]triazol-1-yl-butane-2,3-diol 
• 107659-60-9 (1R,2R)-2-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-3-[1,2,4]triazol-1-yl-propane-1,2-diol 
• 107659-59-6 (1S,2R)-2-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-3-[1,2,4]triazol-1-yl-propane-1,2-diol 
• 107680-30-8 (2S,3R)-1,3-Bis-(4-chloro-phenyl)-2-(4-fluoro-phenyl)-4-[1,2,4]triazol-1-yl-butane-2,3-diol 
• 107680-32-0 (2R,3S)-2-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-1-[1,2,4]triazol-1-yl-hexane-2,3-diol 
• 107679-87-8 1-[(4R,5S)-4-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-[1,3]dioxolan-4-ylmethyl]-1H-[1,2,4]triazole 
• 94147-19-0 2-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-2-hydroxy-3-[1,2,4]triazol-1-yl-propan-1-one 

Relevant articles and documents

Vicinal diaryl azole-based urea derivatives as potential cholesterol lowering agents acting through inhibition of SOAT enzymes

A novel series of vicinal diaryl azole-urea derivatives were synthesized and evaluated for their potential to inhibit SOAT enzyme. Among the reported compounds, compound (12d) emerged as the most potent compound with an IC50value of 2.43?μM. In polaxamer-407 induced lipoprotein lipase inhibition model, compound (12d) reduced triglyceride turnover in?vivo. Compound (12d) also showed dose-dependent prevention of serum total cholesterol and prevention of LDL-C elevation at a dose of 30?mg/kg. Furthermore, compound (12d) showed potential to stop falling levels of serum HDL-C dose-dependently and improved the atherogenic index. Effect of 12d on body weight, plaque formation and development of atherogenic lesions were studied. Toxicological study of compound (12d) indicated that at a dose of 2000?mg/kg, 12d was devoid of any signs of toxicity or mortality.

Synthesis of novel substituted diaryl-1,4-diazepines

In this paper a convenient route to new 2,3-diaryl-substituted 1,4-diazepines is described through cyclization of ethanedione derivatives and 1,3-propanediamine. The ethanedione derivatives required were synthesized by microwave-assisted oxidation from ethanones.