1268720-00-8

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 1268719-97-6 (E)-ethyl 2-acetoxy-3-nitro-4-phenylbut-3-enoate 
• 1072-72-6 Tetrahydrothiopyran-4-one 
• 110-62-3 pentanal 
• 5949-05-3 (S)-Citronellal 
• 18328-11-5 3-benzyl propionaldehyde 
• 108-94-1 cyclohexanone 
• 123-72-8 butyraldehyde 
• 590-86-3 isovaleraldehyde 
• 120-72-9 indole 
• 107-02-8 acrolein 
• 1006-94-6 5-methoxylindole 
• 614-96-0 5-methyl-1H-indole 
• 17422-32-1 5-chloro-1H-indole 

Downstream Products

• 1268720-10-0 ethyl (4S,5R,2Z)-5-benzyl-3-nitro-6-oxo-4-phenylhex-2-enoate 
• 1268720-09-7 ethyl (4S,5R,2Z)-5-formyl-3-nitro-4-phenylhept-2-enoate 
• 1268720-24-6 ethyl (4S,5R)-5-(hydroxymethyl)-6-methyl-3-nitro-4-phenylheptanoate 
• 1268720-25-7 (1S,4R)-(2R,3S)-6-ethoxy-2-isopropyl-4-nitro-6-oxo-3-phenylhexyl-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylate 
• 1268720-22-4 ethyl (4R,5S,2Z)-5-formyl-3-nitro-4-phenylhept-2-enoate 
• 1268719-99-8 ethyl (4S,5R,2Z)-5-formyl-3-nitro-4-phenyloct-2-enoate 
• 1268719-98-7 ethyl (4S,5R,2Z)-5-formyl-6-methyl-3-nitro-4-phenylhept-2-enoate 
• 1268720-23-5 (2S)-ethyl 2-acetoxy-3-nitro-4-phenylbut-(3E)-enoate 
• 1357490-08-4 C₁₇H₁₉NO₆ 
• 1357490-10-8 C₁₇H₁₉NO₅S 
• 1357490-02-8 (R,E)-1-(ethoxycarbonyl)-2-nitro-3-phenylallyl 4-nitrobenzoate 
• 1357490-04-0 (4S,5R)-ethyl 5-(hydroxymethyl)-3-nitro-4-phenylheptanoate 

Relevant academic research and scientific papers

Three-component organocascade kinetic resolution of racemic nitroallylic acetates via sequential iminium/enamine asymmetric catalysis

Nitroallylic acetates 1a-f have been kinetically resolved via an asymmetric three-component coupling that involves indoles, acrolein, and nitroolefin allylic acetates and is mediated by the chiral catalyst 2 (5 mol %). The reactions proceed via iminium/enamine cascade catalysis. Both recovered starting substrates and reaction products are typically obtained in high chemical yield and in good to excellent enantiopurity (79-95% ee for 1a-f and 83-99% ee for 3a-n). For the first time, a highly efficient three-component, organocascade kinetic resolution has been demonstrated.

Kinetic resolution of activated nitroallylic acetates with aldehydes and ketones through a conjugate addition-elimination SN2′ process

A unique organocatalytic kinetic resolution (KR) of nitroallylic acetates has been developed. A variety of racemic nitroallylic acetates (1a-n) were resolved with chiral enamines formed in situ from the reaction of aldehydes and ketones with organocatalys