126934-95-0

Upstream product

• 67-56-1 methanol 
• 3585-53-3 2-(4-phenoxyphenyl)propanoic acid 
• 107727-67-3 Sodium; 1-hydroxy-2-(4-phenoxy-phenyl)-propane-1-sulfonate 
• 80793-26-6 2-(4-Phenoxy-phenyl)-propionaldehyde 
• 124-41-4 sodium methylate 

Downstream Products

• 886359-84-8 (1R,2R,3R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl (2R)-2-fluoro-2-(4-phenoxyphenyl)propionate 
• 863224-91-3 2-fluoro-2-(4-phenoxyphenyl)propionic acid 
• 863224-88-8 methyl 2-fluoro-2-(4-phenoxyphenyl)propionate 

Relevant academic research and scientific papers

Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of Non-steroidal Anti-inflammatory Drugs (NSAIDs)

We report the synthesis of optically active 2-aryl-2-fluoropropionic acids 2 as non-epimerizable mimics of 2-arylpropionic acids 1, a class of compounds which have been widely used as non-steroidal anti-inflammatory drugs (NSAIDs). This is a continuation of our research involving the design, synthesis, and evaluation of chiral fluorine-containing organic molecules as effective analogues of pharmacologically important compounds.

THE OXIDATRION OF ALDEHYDE BISULFITE ADDUCTS TO CARBOXYLIC ACIDS AND THEIR DERIVATIVES WITH DIMETHYLSULFOXIDE AND ACETIC ANHYDRIDE

Bisulfite adducts which are readily formed from aldehydes are conveniently oxidized to carboxylic acids and derivatives by the action of DMSO/Ac2O followed by quenching with water, an alcohol or an amine.