126971-80-0Relevant academic research and scientific papers
With anti-tumor activity of triazole b the nitrogen is outstanding compound and its preparation method (by machine translation)
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, (2018/03/24)
The invention discloses a with anti-tumor activity of triazole b the nitrogen is outstanding compound and its preparation method, which belongs to the technical field of medical synthesis. Technical point of the invention is: The invention compared with the prior art has the following advantages: the invention synthetic method is simple, novel and molecular structure can be integrated two nitrogen test paper compound and the triazole compound of the advantages of biological activity, to the breast cancer cell MCF - 7 and liver cancer cell HepG2 inhibition, is expected to be in the direction of the anti-tumor drugs further popularization and application. (by machine translation)
Azacycloheptane-o-diazepine drug molecule with antitumor activity and preparation method thereof
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, (2018/03/24)
The invention discloses an azacycloheptane-o-diazepine drug molecule with antitumor activity and a preparation method thereof, and belongs to the technical field of medicine synthesis. According to key points of the technical scheme, the novel azacycloheptane-o-diazepine drug molecule disclosed by the invention has the following structure, wherein the structural formula is shown in the specification. The invention further discloses a preparation method of the novel azacycloheptane-o-diazepine drug molecule. The novel azacycloheptane-o-diazepine drug molecule is synthesized according to a novelmethod, the reaction process is simple and feasible in operation, the raw materials are cheap and readily available, and the novel drug molecule is high in reaction efficiency, excellent in repeatability and obvious in antitumor activity and effect.
A novel benzodiazepine three-ring compound and its preparation method and application (by machine translation)
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, (2018/06/15)
The invention discloses a novel benzodiazepine three-ring compound and its preparation method and application, which belongs to the technical field of medical synthesis. Technical proposal of the invention points are: a novel benzodiazepine three-ring compound, has the following structure: Wherein R is O or S. The invention also discloses a novel benzodiazepine tricyclic compound of the preparation method. The invention a new method to synthesize a novel benzodiazepine three-ring compound, the reaction process is simple and easy operation, the raw material is cheap, environmental protection, higher reaction efficiency and good repeatability, has good anti-platelet aggregation activity and anti-tumor activity. (by machine translation)
4-substituted benzodiazepine 2-one compounds with anti-platelet aggregation activity and supercritical preparation method of 4-substituted benzodiazepine 2-one compounds
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, (2018/04/26)
The invention discloses 4-substituted benzodiazepine 2-one compounds and a supercritical preparation method thereof, and belongs to the technical field of synthesis of pharmaceutical intermediates. The technical scheme is that the 4-substituted benzodiazepine 2-one compounds have the structure shown in the description, wherein R is methyl, ethyl, propyl, isopropyl, cyclopropyl or cyclohexyl. The invention further discloses the supercritical preparation method of the 4-substituted benzodiazepine 2-one compounds. The 4-substituted benzodiazepine 2-one compounds are synthesized with a novel method, the reaction process is simple and feasible to operate, the raw materials are cheap, easily available and environmentally friendly, the reaction efficiency is higher, and the repeatability is better.
2-amino substituted benzodiarizonaepine compound with antineoplastic activity and preparation method thereof
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, (2018/05/01)
The invention discloses a 2-amino substituted benzodiarizonaepine compound with antineoplastic activity and a preparation method thereof, and belongs to the technical field of medicine synthesis. Thetechnical character of the compound is shown in the specification, wherein R is CH3, C2H5, C3H7 and phenyl. Compared with the prior art, the compound has the benefits that the synthesis method is simple, the molecular structure is novel, the reaction effect repeatability is good, the compound has inhibiting effect on both breast cancer cell MCF-7 and hepatocarcinoma cell HepG2, and is expected tobe further promoted and applied.
Bioactive 3,4,5-substituted benzodiazepine 2-one drug molecules and preparation method thereof
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Paragraph 0031; 0032, (2018/04/26)
The invention discloses bioactive 3,4,5-substituted benzodiazepine 2-one drug molecules and a preparation method thereof and belongs to the technical field of drug synthesis. The technical scheme is characterized in that the structure of the compounds is shown in the description, wherein R1 is methyl, pyridyl, phenyl or isopropyl; R1 and R2 are selected from methyl, ethyl or phenyl independently respectively. Compared with the prior art, the compounds and the preparation method have the following beneficial effects: the synthesis method is simple, the molecular structure is novel, and the compounds have an inhibition effect on the leukemia cell line K562 and the breast cancer cell MCF-7 and are expected to be further popularized and applied.
From five- to six-membered rings: 3,4-Diarylquinolinone as lead for novel p38MAP kinase inhibitors
Peifer, Christian,Kinkel, Katrin,Abadleh, Mohammed,Schollmeyer, Dieter,Laufer, Stefan
, p. 1213 - 1221 (2007/10/03)
In this study we describe the design, synthesis, and biological evaluation of 3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one (5) as a new inhibitor of MAPK with a p38αMAPK IC50 of 1.8 μM. By keeping the common vicinal pyridine/4-F-phenyl
